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PROTAC K-Ras Degrader-1

Name: PROTAC K-Ras Degrader-1
Brand: TargetMol
SKU: T13844
Rating: 4.5 (1 reviews)

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Catalog No. T13844Cas No. 2378258-52-5

PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligand, capable of degrading K-Ras.

PROTAC K-Ras Degrader-1

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Purity: 98.05%

Catalog No. T13844Cas No. 2378258-52-5

PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligand, capable of degrading K-Ras.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$839	Backorder	Backorder
5 mg	$1,240	Backorder	Backorder
10 mg	$1,990	Backorder	Backorder
50 mg	Inquiry	Backorder	Backorder
100 mg	Inquiry	Backorder	Backorder

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.05%

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COA

Product Introduction

Bioactivity

Description

PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligand, capable of degrading K-Ras.

Chemical Properties

Molecular Weight	999.12
Formula	C₅₃H₆₂N₁₀O₁₀
Cas No.	2378258-52-5
Smiles	O(C[C@@H]1C[C@@H](OCCOCCOCCOCCNC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)CN1C)C5=NC(=C6C(CN(CC6)C=7C8=C(C=CC7)C=CC=C8)=N5)N9C[C@H](CC#N)N(C(C=C)=O)CC9
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (25.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0009 mL	5.0044 mL	10.0088 mL	50.0440 mL
5 mM	0.2002 mL	1.0009 mL	2.0018 mL	10.0088 mL
10 mM	0.1001 mL	0.5004 mL	1.0009 mL	5.0044 mL
20 mM	0.0500 mL	0.2502 mL	0.5004 mL	2.5022 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc