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VU0155041

Name: VU0155041
Brand: TargetMol
SKU: T3565
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3565Cas No. 1093757-42-6

Alias VU-0155041, UV0155041

VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).

VU0155041

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Purity: 99.56%

Catalog No. T3565Alias VU-0155041, UV0155041Cas No. 1093757-42-6

VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	In Stock
5 mg	$53	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$317	In Stock	In Stock
200 mg	$458	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:White to Red

Resource Download

COA HNMR HPLC

Product Introduction

VU0155041 AI Summary

VU0155041 is an allosteric modulator of the human mGlu4 receptor, exhibiting positive modulation of calcium flux in both CHO cells coexpressing Gqi5 and BHK cells, with Emax values of 127.0% and 120.0%, respectively, relative to glutamate. The compound has EC50 values of 740.0 nM and 750.0 nM for its allosteric modulator activity in the respective assays. Additionally, VU0155041 demonstrates antiviral properties against SARS-CoV-2, inhibiting the SARS-CoV-2 3CL-Pro protease by 17.63% at 20 µM as measured via a FRET assay, and reducing SARS-CoV-2 induced cytotoxicity in VERO-6 cells by 0.43% at 10 µM after 48 hours of exposure, as assessed by high content imaging..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
Targets&IC50	mGlu4 (rat):693 nM(EC50), mGlu4 (human):798nM(EC50)
Synonyms	VU-0155041, UV0155041

Chemical Properties

Molecular Weight	316.18
Formula	C₁₄H₁₅Cl₂NO₃
Cas No.	1093757-42-6
Smiles	OC(=O)[C@H]1CCCC[C@H]1C(=O)Nc1cc(Cl)cc(Cl)c1
Relative Density.	1.429 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31.6 mg/mL (99.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1628 mL	15.8138 mL	31.6276 mL	158.1378 mL
5 mM	0.6326 mL	3.1628 mL	6.3255 mL	31.6276 mL
10 mM	0.3163 mL	1.5814 mL	3.1628 mL	15.8138 mL
20 mM	0.1581 mL	0.7907 mL	1.5814 mL	7.9069 mL
50 mM	0.0633 mL	0.3163 mL	0.6326 mL	3.1628 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc