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N-Acetylneuraminic acid

Name: N-Acetylneuraminic acid
Brand: TargetMol
SKU: T1638
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1638Cas No. 131-48-6

Alias NeuAc, Lactaminic acid, Acide aceneuramique

N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown that N-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infections, and carbohydrate-protein recognition.

N-Acetylneuraminic acid

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Purity: 99.97%

Catalog No. T1638Alias NeuAc, Lactaminic acid, Acide aceneuramiqueCas No. 131-48-6

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$48	In Stock	In Stock
1 g	$68	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

N-Acetylneuraminic acid AI Summary

N-Acetylneuraminic acid exhibits a range of inhibitory and bioactive properties. It has been tested for inhibition of Influenza sialidase type A and type B, with an IC50 of 1000000.0 nM in both assays, indicating potential but low-level inhibitory effects. The compound is effective in several bioassays: - It counters cytotoxicity in the Nrf2 qHTS screen with a potency of 651.3 nM. - It inhibits Importin-beta complex formation in the Rango assay with a potency of 125892.5 nM. - It inhibits HP1-beta Chromodomain interactions with methylated histone tails with a potency of 89125.1 nM. - It demonstrates inhibitory activity against Hepatitis C Virus (HCV) with a potency of 3162.3 nM. - It exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (16.52% inhibition at 10 µM after 48 hours) and against the SARS-CoV-2 3CL-Pro protease (41.21% at 20 µM). However, the compound shows lower efficacy in inhibiting SARS-CoV-2 cytotoxicity in VERO-6 cells, with IC50 values above 50100.0 nM. Additionally, N-Acetylneuraminic acid moderately inhibits human HDAC6 (-21.56% using a commercial peptide substrate) but shows no significant inhibition against human NEU1, NEU2, NEU3, and NEU4, with IC50 values greater than 500000.0 nM. The compound also has a dissociation constant (pKa) of 3.2. Further studies are necessary to fully understand its bioactivity and therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown that N-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infections, and carbohydrate-protein recognition.
Synonyms	NeuAc, Lactaminic acid, Acide aceneuramique

Chemical Properties

Molecular Weight	309.27
Formula	C₁₁H₁₉NO₉
Cas No.	131-48-6
Smiles	[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)([C@H](CC(C(O)=O)=O)O)NC(C)=O
Relative Density.	1.3580 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 125 mg/mL (404.18 mM), Sonication is recommended.

DMSO: 122 mg/mL (394.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.2334 mL	16.1671 mL	32.3342 mL	161.6710 mL
5 mM	0.6467 mL	3.2334 mL	6.4668 mL	32.3342 mL
10 mM	0.3233 mL	1.6167 mL	3.2334 mL	16.1671 mL
20 mM	0.1617 mL	0.8084 mL	1.6167 mL	8.0836 mL
50 mM	0.0647 mL	0.3233 mL	0.6467 mL	3.2334 mL
100 mM	0.0323 mL	0.1617 mL	0.3233 mL	1.6167 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc