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Thalidomide-NH-CH2-COOH

Name: Thalidomide-NH-CH2-COOH
Brand: TargetMol
SKU: T40016
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40016Cas No. 927670-97-1

Alias 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid, (2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine

Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.

Thalidomide-NH-CH2-COOH

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Purity: 96.3800%

Catalog No. T40016Alias 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid, (2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycineCas No. 927670-97-1

Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.

Pack Size	Price	Availability	Quantity
10 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:96.3800%

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Product Introduction

Bioactivity

Description	Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.
In vitro	PROTACs are composed of two distinct ligands joined by a linker: one ligand targets an E3 ubiquitin ligase, while the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade the target proteins[1].
Synonyms	2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid, (2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine

Chemical Properties

Molecular Weight	331.28
Formula	C₁₅H₁₃N₃O₆
Cas No.	927670-97-1
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCC(O)=O
Relative Density.	1.637 g/cm3 (Predicted)
Color	Green
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 42.5 mg/mL (128.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0186 mL	15.0930 mL	30.1859 mL	150.9297 mL
5 mM	0.6037 mL	3.0186 mL	6.0372 mL	30.1859 mL
10 mM	0.3019 mL	1.5093 mL	3.0186 mL	15.0930 mL
20 mM	0.1509 mL	0.7546 mL	1.5093 mL	7.5465 mL
50 mM	0.0604 mL	0.3019 mL	0.6037 mL	3.0186 mL
100 mM	0.0302 mL	0.1509 mL	0.3019 mL	1.5093 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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