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AR antagonist 1

Name: AR antagonist 1
Brand: TargetMol
SKU: T10359
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10359Cas No. 1818885-54-9

AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.

AR antagonist 1

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Purity: 99.07%

Catalog No. T10359Cas No. 1818885-54-9

AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.

Pack Size	Price	Availability
1 mg	$55	In Stock
5 mg	$127	In Stock
10 mg	$188	In Stock
25 mg	$310	In Stock
50 mg	$413	In Stock
100 mg	$580	In Stock
200 mg	$789	In Stock
1 mL x 10 mM (in DMSO)	$121	In Stock

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Purity:99.07%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
Targets&IC50	Androgen receptor:
In vitro	AR antagonist 1 (compound 29) is the ligand for the target ligase of ARD-266, a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. AR antagonist 1 exhibits micromolar binding affinity to its E3 ligase complex and can be effectively used in designing potent and efficient PROTAC degraders.

Chemical Properties

Molecular Weight	278.78
Formula	C₁₅H₁₉ClN₂O
Cas No.	1818885-54-9
Smiles	CC1(C)[C@H](N)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1
Relative Density.	1.18 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (215.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5871 mL	17.9353 mL	35.8706 mL	179.3529 mL
5 mM	0.7174 mL	3.5871 mL	7.1741 mL	35.8706 mL
10 mM	0.3587 mL	1.7935 mL	3.5871 mL	17.9353 mL
20 mM	0.1794 mL	0.8968 mL	1.7935 mL	8.9676 mL
50 mM	0.0717 mL	0.3587 mL	0.7174 mL	3.5871 mL
100 mM	0.0359 mL	0.1794 mL	0.3587 mL	1.7935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc