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4E2RCat
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Catalog No. T14044Cas No. 432499-63-3
4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and effectively blocks coronavirus replication, as evidenced by reduced viral protein expression and decreased production of infectious virus.
4E2RCat
🥰Excellent
Purity: 98.44%
Catalog No. T14044Cas No. 432499-63-3
4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and effectively blocks coronavirus replication, as evidenced by reduced viral protein expression and decreased production of infectious virus.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $35 | In Stock | In Stock | |
| 25 mg | $83 | In Stock | In Stock | |
| 50 mg | $143 | In Stock | In Stock | |
| 100 mg | $247 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $197 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.44%
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Product Introduction
Bioactivity
Chemical Properties
| Description | 4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and effectively blocks coronavirus replication, as evidenced by reduced viral protein expression and decreased production of infectious virus. |
| Targets&IC50 | eIF4E-eIF4G:13.5 μM |
| In vitro | 4E2RCat disrupts the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), thereby inhibiting cap-dependent translation. This action significantly reduces replication of human coronavirus 229E (HCoV-229E), decreasing both the proportion of infected cells and the levels of infectious virus both inside and outside cells. The inhibition of cap-dependent translation by 4E2RCat occurs in a dose-dependent manner, specifically targeting cap-dependent FF translation without affecting EMCV IRES-driven Ren translation. Additionally, 4E2RCat curtails coronavirus replication reliant on dose and duration[1]. |
| In vivo | 4E2RCat impedes protein synthesis in vivo, and this effect is not due to elevated cell death[1]. |
| Molecular Weight | 455.93 |
| Formula | C22H14ClNO4S2 |
| Cas No. | 432499-63-3 |
| Smiles | OC(=O)c1cc(ccc1Cl)-c1ccc(\C=C2/SC(=S)N(Cc3ccccc3)C2=O)o1 |
| Relative Density. | 1.56 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 15.5 mg/mL (34.00 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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