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Zomiradomide

Name: Zomiradomide
Brand: TargetMol
SKU: T75136
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75136Cas No. 2655656-99-6

Alias KT-413, KT413, IRAK degrader-1

Zomiradomide is a PROTAC degradation agent targeting IRAK4, with oral bioavailability, and can also degrade Ikaros (IKZF1) and Aiolos (IKZF3), thereby inhibiting the NF-κB signalling pathway and activating the type I interferon signalling pathway, exhibiting anticancer activity against B-cell lymphoma.

Zomiradomide

🥰Excellent

Purity: 98.41%

Catalog No. T75136Alias KT-413, KT413, IRAK degrader-1Cas No. 2655656-99-6

Pack Size	Price	Availability
1 mg	$158	In Stock
5 mg	$283	In Stock
10 mg	$425	In Stock

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.41%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Zomiradomide is a PROTAC degradation agent targeting IRAK4, with oral bioavailability, and can also degrade Ikaros (IKZF1) and Aiolos (IKZF3), thereby inhibiting the NF-κB signalling pathway and activating the type I interferon signalling pathway, exhibiting anticancer activity against B-cell lymphoma.
In vitro	Method: The diffuse large B-cell lymphoma (DLBCL) cell line OCI-Ly10 carrying the Myd88 L265P mutation was treated with various concentrations of Zomiradomide to assess its antiproliferative effect and determine the IC₅₀ value. Result: Zomiradomide effectively inhibited the proliferation of OCI-Ly10 cells, with an IC₅₀ of 11 nM. [2]
In vivo	Method: In OCI-Ly10 xenograft mouse models, Zomiradomide was administered orally at doses of 3–30 mg/kg once daily for 3 consecutive days to evaluate its antitumor effect. Result: Zomiradomide significantly inhibited tumor growth. [2]
Synonyms	KT-413, KT413, IRAK degrader-1

Chemical Properties

Molecular Weight	871.97
Formula	C₄₅H₄₈F₃N₇O₆S
Cas No.	2655656-99-6
Smiles	C(N1CC2(C1)CC(CCNC3=C4C(C(=O)N(C4=O)C5C(=O)NC(=O)CC5)=CC=C3)C2)[C@H]6CC[C@@H](CC6)C=7SC=8C(N7)=CC(C(C)(C)O)=C(NC(=O)C=9N=C(C(F)(F)F)C=CC9)C8
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (172.02 mM), Sonication is recommended.

In Vivo Formulation

2% DMSO+40% PEG300+5% Tween 80+53% Saline: 3 mg/mL (3.44 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1468 mL	5.7341 mL	11.4683 mL	57.3414 mL
5 mM	0.2294 mL	1.1468 mL	2.2937 mL	11.4683 mL
10 mM	0.1147 mL	0.5734 mL	1.1468 mL	5.7341 mL
20 mM	0.0573 mL	0.2867 mL	0.5734 mL	2.8671 mL
50 mM	0.0229 mL	0.1147 mL	0.2294 mL	1.1468 mL
100 mM	0.0115 mL	0.0573 mL	0.1147 mL	0.5734 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Zomiradomide

Zomiradomide

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