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N106

Name: N106
Brand: TargetMol
SKU: T28124
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28124Cas No. 862974-25-2

Alias N-106, N 106

N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.

N106

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Purity: 99.69%

Catalog No. T28124Alias N-106, N 106Cas No. 862974-25-2

N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$43	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$178	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$589	In Stock	In Stock
100 mg	$843	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.69%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.
In vitro	N106 (10 min) increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation. These effects are sustained at 24 h in cardiomyocytes[1].
In vivo	N106 (10 mg/kg) significantly improves ventricular function in mice with heart failure. N106(10 mg/kg; i.v.) exhibits a half-life of 65.4 min and a Cmax of ∼2.24 μM[1].
Synonyms	N-106, N 106

Chemical Properties

Molecular Weight	354.38
Formula	C₁₇H₁₄N₄O₃S
Cas No.	862974-25-2
Smiles	COc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1
Relative Density.	1.390 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 56.7 mg/mL (160 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8218 mL	14.1091 mL	28.2183 mL	141.0915 mL
5 mM	0.5644 mL	2.8218 mL	5.6437 mL	28.2183 mL
10 mM	0.2822 mL	1.4109 mL	2.8218 mL	14.1091 mL
20 mM	0.1411 mL	0.7055 mL	1.4109 mL	7.0546 mL
50 mM	0.0564 mL	0.2822 mL	0.5644 mL	2.8218 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc