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N106

Name: N106
Brand: TargetMol
SKU: T28124
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28124Cas No. 862974-25-2

Alias N-106, N 106

N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.

N106

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Purity: 99.69%

Catalog No. T28124Alias N-106, N 106Cas No. 862974-25-2

N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$43	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$178	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$589	In Stock	In Stock
100 mg	$843	-	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.69%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.
In vitro	N106 (10 min) increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation. These effects are sustained at 24 h in cardiomyocytes[1].
In vivo	N106 (10 mg/kg) significantly improves ventricular function in mice with heart failure. N106(10 mg/kg; i.v.) exhibits a half-life of 65.4 min and a Cmax of ∼2.24 μM[1].
Synonyms	N-106, N 106

Chemical Properties

Molecular Weight	354.38
Formula	C₁₇H₁₄N₄O₃S
Cas No.	862974-25-2
Smiles	COc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1
Relative Density.	1.390 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 56.7 mg/mL (160 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8218 mL	14.1091 mL	28.2183 mL	141.0915 mL
5 mM	0.5644 mL	2.8218 mL	5.6437 mL	28.2183 mL
10 mM	0.2822 mL	1.4109 mL	2.8218 mL	14.1091 mL
20 mM	0.1411 mL	0.7055 mL	1.4109 mL	7.0546 mL
50 mM	0.0564 mL	0.2822 mL	0.5644 mL	2.8218 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc