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Tefinostat

Name: Tefinostat
Brand: TargetMol
SKU: T17028
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17028Cas No. 914382-60-8

Alias CHR-2845

Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor that is cleaved to the active acid CHR-2847 by intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.

Tefinostat

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Purity: 99.83%

Catalog No. T17028Alias CHR-2845Cas No. 914382-60-8

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$239	In Stock
10 mg	$355	In Stock
25 mg	$537	In Stock
50 mg	$712	In Stock
100 mg	$1,120	In Stock
1 mL x 10 mM (in DMSO)	$258	In Stock

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Purity:99.83%

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Bioactivity

Description	Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor that is cleaved to the active acid CHR-2847 by intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.
In vitro	Tefinostat (1-4 nM; AML cell lines) demonstrates efficacy in AML cell lines, including HL60 (M2 FAB type), MV411 (M4, FLT3-ITD), OCIAML3 (M4 NPM1mut), and THP1 (M5), with EC50 values of 2.3 μM, 57 nM, 110 nM, and 560 nM, respectively.
Synonyms	CHR-2845

Chemical Properties

Molecular Weight	495.61
Formula	C₂₈H₃₇N₃O₅
Cas No.	914382-60-8
Smiles	ONC(=O)CCCCCCC(=O)Nc1ccc(CN[C@H](C(=O)OC2CCCC2)c2ccccc2)cc1
Relative Density.	1.21 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (181.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0177 mL	10.0886 mL	20.1772 mL	100.8858 mL
5 mM	0.4035 mL	2.0177 mL	4.0354 mL	20.1772 mL
10 mM	0.2018 mL	1.0089 mL	2.0177 mL	10.0886 mL
20 mM	0.1009 mL	0.5044 mL	1.0089 mL	5.0443 mL
50 mM	0.0404 mL	0.2018 mL	0.4035 mL	2.0177 mL
100 mM	0.0202 mL	0.1009 mL	0.2018 mL	1.0089 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc