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UK 227786

Name: UK 227786
Brand: TargetMol
SKU: T11220L
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11220LCas No. 150452-21-4

Alias hydrochloride(150452-18-9 Free base), 1-[4-(1,3-Benzodioxol-5a-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylic acid;hydrochloride(150452-18-9 Free base), 1-[4-(1,3-Benzodioxol-5a-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylic acid

UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.

UK 227786

🥰Excellent

Purity: 99.9%

Catalog No. T11220LAlias hydrochloride(150452-18-9 Free base), 1-[4-(1,3-Benzodioxol-5a-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylic acid;hydrochloride(150452-18-9 Free base), 1-[4-(1,3-Benzodioxol-5a-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylic acidCas No. 150452-21-4

UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.

Pack Size	Price	Availability
1 mg	$117	In Stock
2 mg	$175	In Stock
5 mg	$269	In Stock
10 mg	$395	In Stock
25 mg	$592	In Stock
50 mg	$834	In Stock
100 mg	$1,120	In Stock
500 mg	$2,260	In Stock
1 mL x 10 mM (in DMSO)	$321	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.9%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.
Synonyms	hydrochloride(150452-18-9 Free base), 1-[4-(1,3-Benzodioxol-5a-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylic acid;hydrochloride(150452-18-9 Free base), 1-[4-(1,3-Benzodioxol-5a-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylic acid

Chemical Properties

Molecular Weight	477.34
Formula	C₂₂H₂₂Cl₂N₄O₄
Cas No.	150452-21-4
Smiles	Cl.OC(=O)C1CCN(CC1)c1nc(NCc2ccc3OCOc3c2)c2cc(Cl)ccc2n1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (115.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0949 mL	10.4747 mL	20.9494 mL	104.7471 mL
5 mM	0.4190 mL	2.0949 mL	4.1899 mL	20.9494 mL
10 mM	0.2095 mL	1.0475 mL	2.0949 mL	10.4747 mL
20 mM	0.1047 mL	0.5237 mL	1.0475 mL	5.2374 mL
50 mM	0.0419 mL	0.2095 mL	0.4190 mL	2.0949 mL
100 mM	0.0209 mL	0.1047 mL	0.2095 mL	1.0475 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc