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U3-1784
(Synonyms: U31784) Copy Product Info
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Synonyms: U31784
Catalog No. T77453 Copy Product Info
🥰Excellent
U3-1784 is a humanized antibody that targets CD334. U3-1784 exerts its antitumor activity by binding to FGFR4 with high affinity and selectivity, thereby blocking its interaction with ligands. U3-1784 can be used in research on liver cancer.
U3-1784
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $158 | - | In Stock | |
| 5 mg | $477 | - | In Stock | |
| 10 mg | $767 | - | In Stock | |
| 25 mg | $1,130 | Inquiry | Inquiry | |
| 50 mg | Preferential | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.95% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | U3-1784 is a humanized antibody that targets CD334. U3-1784 exerts its antitumor activity by binding to FGFR4 with high affinity and selectivity, thereby blocking its interaction with ligands. U3-1784 can be used in research on liver cancer. |
| Targets & IC50 | FGFR4:2 nmol/L |
| In vitro | U3-1784 showed excellent specificity for FGFR4 and did not bind to other FGFR with Kd =0.3 nmol/L and IC50 value of 2 nmol/L. [1] |
| In vivo | Methods: Ten liver cancer xenograft models (cell-derived/patient-derived) were established. U3-1784 (25 mg/kg) was administered intraperitoneally twice weekly to evaluate synergistic antitumor effects and monitor tumor volume and mouse body weight. Results: U3-1784 was effective only in FGF19-positive liver cancer models, with a maximum tumor suppression rate of 90%. [1] Methods: Rhesus monkeys were administered intravenous injections of U3-1784 (100 mg/kg, once every 7 days, for a total of 3 doses), and serum bile acid and liver enzyme (ALT/AST) levels were measured. Results: U3-1784 elevated bile acid and liver enzyme levels, inducing liver damage.[1] |
| Synonyms | U31784 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | FGFR4/CD334 |
| Molecular Weight | 143.22 kDa |
| Smiles | #N/A |
| Isotype | Human IgG1 lambda2 |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: U3-1784 in vivo | U3-1784 in vitro | U3-1784 molecular weight
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