CDNF Protein, Human, Recombinant (His)

Name: CDNF Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-00568
Rating: 4.5 (1 reviews)

(Synonyms: cerebral dopamine neurotrophic factor, ARMETL1) Copy Product Info

Synonyms: cerebral dopamine neurotrophic factor, ARMETL1

Catalog No. TMPY-00568 Copy Product Info

CDNF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q49AH0-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$78	7-10 days	7-10 days
10 µg	$129	7-10 days	7-10 days
20 µg	$213	7-10 days	7-10 days
50 µg	$333	7-10 days	7-10 days
100 µg	$535	7-10 days	7-10 days
200 µg	$793	7-10 days	7-10 days
500 µg	$1,690	7-10 days	7-10 days
1 mg	$3,420	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	CDNF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q49AH0-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q49AH0-1
Construction	A DNA sequence encoding the human CDNF (NP_001025125.2) (Met1-Leu187) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Gln 25
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	cerebral dopamine neurotrophic factor, ARMETL1
Research Background	Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.

Chemical Properties

Molecular Weight

20 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.