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PSB-15160

Name: PSB-15160
Brand: TargetMol
SKU: T69860
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69860Cas No. 215997-93-6

PSB-15160 is a compound that inhibits the growth of MCF7 (breast), NCI-H460 (lung) and SF-268 (NCS) cells in the treatment of estrogen-dependent tumours.

PSB-15160

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Purity: 97.22%

Catalog No. T69860Cas No. 215997-93-6

PSB-15160 is a compound that inhibits the growth of MCF7 (breast), NCI-H460 (lung) and SF-268 (NCS) cells in the treatment of estrogen-dependent tumours.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
5 mg	$440	In Stock	In Stock
10 mg	$648	In Stock	In Stock
25 mg	$987	In Stock	In Stock
50 mg	$1,390	In Stock	In Stock
100 mg	$1,870	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.22%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

PSB-15160 AI Summary

PSB-15160 exhibits bioactivity as an agonist at the Gi-coupled human GPR84 receptor expressed in CHO cells, inhibiting forskolin-induced cAMP accumulation with an EC50 value of 80.0 nM. Additionally, it demonstrates beta-arrestin recruitment at the same receptor after 90 minutes, with an EC50 value of 4330.0 nM. The compound acts as a positive allosteric modulator of recombinant human GPR84, leading to a 125.0% increase in [3H]PSB-1584 binding, with an EC50 value of 199.0 nM as measured by scintillation counting after 6 hours. It also exhibits stability in pH 1.2 artificial gastric fluid at a level of 57.0%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PSB-15160 is a compound that inhibits the growth of MCF7 (breast), NCI-H460 (lung) and SF-268 (NCS) cells in the treatment of estrogen-dependent tumours.
Targets&IC50	GPR84:41.3 nM(EC50)

Chemical Properties

Molecular Weight	282.29
Formula	C₁₇H₁₂F₂N₂
Cas No.	215997-93-6
Smiles	C(C=1C=2C(NC1)=CC=C(F)C2)C=3C=4C(NC3)=CC=C(F)C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (212.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5425 mL	17.7123 mL	35.4246 mL	177.1228 mL
5 mM	0.7085 mL	3.5425 mL	7.0849 mL	35.4246 mL
10 mM	0.3542 mL	1.7712 mL	3.5425 mL	17.7123 mL
20 mM	0.1771 mL	0.8856 mL	1.7712 mL	8.8561 mL
50 mM	0.0708 mL	0.3542 mL	0.7085 mL	3.5425 mL
100 mM	0.0354 mL	0.1771 mL	0.3542 mL	1.7712 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc