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Anti-Prolactin Receptor Antibody (8B416)
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Catalog No. TMAY-00549
Alias prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712
Anti-Prolactin Receptor Antibody (8B416) is a Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody (8B416) can be used in ELISA,ELISA(Det).
Anti-Prolactin Receptor Antibody (8B416)
Anti-Prolactin Receptor Antibody (8B416)
😃Good
Catalog No. TMAY-00549Alias prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712
Anti-Prolactin Receptor Antibody (8B416) is a Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody (8B416) can be used in ELISA,ELISA(Det).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $93 | 7-10 days | |
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA, ELISA(Det) Reactivity: Human |
| Alias | prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712 |
| Ig Type | Rabbit IgG |
| Clone | 8B416 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of human PRLR expression on MCF-7 cells. Cells were stained with purified anti-Human PRLR, then a FITC-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells. |
| Application | ELISA,ELISA(Det) |
| Recommended Dose | ELISA: 1:5000-1:10000; ELISA(Det): 1:1000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human PRLR (rh PRLR; TMPY-01053; NP_000940.1; Met 1-Asp 234). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules involved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer. |
| Conjucates | Unconjugated |
| Others Formats | APC/HRP/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Protein: Human PRLR protein (TMPY-01053) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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