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Piperonyl butoxide

Name: Piperonyl butoxide
Brand: TargetMol
SKU: T0727
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0727Cas No. 51-03-6

Alias Pyrenone 606, Ethanol butoxide, ENT-14250, Butacide

Piperonyl butoxide (Pyrenone 606) is an insecticide synergist, particularly for rotenone and pyrethroids.

Piperonyl butoxide

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Purity: 99.84%

Catalog No. T0727Alias Pyrenone 606, Ethanol butoxide, ENT-14250, ButacideCas No. 51-03-6

Piperonyl butoxide (Pyrenone 606) is an insecticide synergist, particularly for rotenone and pyrethroids.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
200 mg	$48	In Stock	In Stock
500 mg	$64	In Stock	In Stock
1 g	$93	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR GC LCMS

Product Introduction

Piperonyl butoxide AI Summary

Piperonyl butoxide exhibits a diverse range of bioactivities. It acts as an agonist on the Thyroid Stimulating Hormone Receptor and as an antagonist of the peroxisome proliferator-activated receptor delta signaling. Additionally, it inhibits enzymes such as Aldehyde Dehydrogenase 1 (ALDH1A1), human tyrosyl-DNA phosphodiesterase 1 (TDP1), and the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. Notably, it influences the Cytochrome P450 3A4 enzyme as both an activator and inhibitor/substrate and demonstrates activating effects on both rat and human pregnane X receptor (PXR) signaling pathways. Piperonyl butoxide also blocks the entry of the Ebola virus and shows gametocytocidal activity. In agricultural contexts, Piperonyl butoxide exhibits insecticidal properties. Against Frankliniella occidentalis (western flower thrips), it gave a 10.0% mortality rate at a concentration of 1000 mg/l and inhibits total esterase activity with IC50 values between 1910000.0 nM and 2670000.0 nM. It also inhibits B-type Bemisia tabaci (sweet potato whitefly) enzyme activity, showing significant reduction in oxidase-mediated O-deethylation and esterase activity. For Tetranychus urticae (two-spotted spider mite) larvae, it increases mortality rates, especially when combined with spirodiclofen and cytochrome P450 monooxygenase inhibitor, PBO. Additionally, in Wistar rat liver microsomes, it inhibits both aniline hydroxylase and aminopyrine demethylase activities with an IC50 value of 420,000.0 nM. As a CYP3A4 enzyme inhibitor relevant to retinoic acid metabolism, it has an IC50 value of 3000.0 nM, suggesting potential as a Retinoic Acid Metabolism Blocking Agent (RAMBA). For its impact on human BSEP (Bile Salt Export Pump) activity, Piperonyl butoxide shows an IC50 value of less than 10,000.0 nM in baculovirus transfected cell membranes. It demonstrates antiviral capabilities against SARS-CoV-2 (strain BavPat1) with an inhibition index of 0.8723 in infected Vero E6 cells and a hit score of 0.1894 in HRCE cells for the USA-WA1/2020 strain, though its efficacy is less compared to controls like arbidol..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Piperonyl butoxide (Pyrenone 606) is an insecticide synergist, particularly for rotenone and pyrethroids.
Synonyms	Pyrenone 606, Ethanol butoxide, ENT-14250, Butacide

Chemical Properties

Molecular Weight	338.44
Formula	C₁₉H₃₀O₅
Cas No.	51-03-6
Smiles	C(OCCOCCOCCCC)C=1C=C2C(=CC1CCC)OCO2
Relative Density.	0.001 g/L. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (147.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9547 mL	14.7737 mL	29.5473 mL	147.7367 mL
5 mM	0.5909 mL	2.9547 mL	5.9095 mL	29.5473 mL
10 mM	0.2955 mL	1.4774 mL	2.9547 mL	14.7737 mL
20 mM	0.1477 mL	0.7387 mL	1.4774 mL	7.3868 mL
50 mM	0.0591 mL	0.2955 mL	0.5909 mL	2.9547 mL
100 mM	0.0295 mL	0.1477 mL	0.2955 mL	1.4774 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc