CHRDL1 Protein, Human, Recombinant (His)

CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis.The hypermethylation of the CHRDL1 promoter in gastric cancer, which induced low expression of CHRDL1 and decreased its secretion to the supernatant.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 511.00
500 μg	5 days	$ 2,040.00
1 mg	5 days	$ 3,410.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 511.00

500 μg

5 days

$ 2,040.00

1 mg

5 days

$ 3,410.00

Description

Species	Human
Expression System	E. coli
Tag	N-His
Accession Number	Q9BU40-1
Synonyms	VOPT, Ventroptin, Neuralin-1, dA141H5.1, CHL, Chordin-like 1, CRDL1, NRLN1, CHRDL1, Neurogenesin-1
Construction	Glu28-Cys456
Protein Purity	> 90% as determined by Tris-Bis PAGE
Molecular Weight	50 kDa (predicted) same as Tris-Bis PAGE result.

Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 4 mM HCl. Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in 4mM HCl. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis.The hypermethylation of the CHRDL1 promoter in gastric cancer, which induced low expression of CHRDL1 and decreased its secretion to the supernatant.