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Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody

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Catalog No. TMAC-00128

Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody is a Rabbit antibody targeting Phospho-AKT1/2/3 (Tyr315/316/312). Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody can be used in WB,IHC,IF.

Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody

Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody

😃Good
Catalog No. TMAC-00128
Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody is a Rabbit antibody targeting Phospho-AKT1/2/3 (Tyr315/316/312). Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody can be used in WB,IHC,IF.
Pack SizePriceAvailabilityQuantity
50 μL$2187-10 days
100 μL$3177-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody is a Rabbit antibody targeting Phospho-AKT1/2/3 (Tyr315/316/312). Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody can be used in WB,IHC,IF.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundGeneral protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
11501
Antigen Species
Peptide sequence around phosphorylation site of tyrosine 315/316/312 (P-E-Y(p)-L-A) derived from Human AKT1/AKT2/AKT3
Uniprot ID
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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