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Ieramilimab
(Synonyms: NVP-LAG525, NVPLAG525, LAG525, LA525, IMP701, IM701) Copy Product Info
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Synonyms: NVP-LAG525, NVPLAG525, LAG525, LA525, IMP701, IM701
Catalog No. T78247 Copy Product Info
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Ieramilimab (LAG525) is a humanized antibody that targets LAG-3; it blocks the interaction between LAG-3 and MHC-II molecules by binding to LAG-3. By blocking the binding of LAG-3 to MHC-II, ieramilimab restores the immune function of T cells and NK cells, including reducing T cell exhaustion, enhancing cytokine production, and increasing cytotoxicity. Ieramilimab also increases the infiltration of cytotoxic T lymphocytes into tumor tissue, reduces the baseline density of regulatory T cells, and improves the tumor immune microenvironment. Ieramilimab is being studied for use in the treatment of various malignant tumors.
Ieramilimab
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $150 | - | In Stock | |
| 5 mg | $378 | - | In Stock | |
| 10 mg | $603 | - | In Stock | |
| 25 mg | $903 | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.4% (SDS-PAGE); 97.8% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Ieramilimab (LAG525) is a humanized antibody that targets LAG-3; it blocks the interaction between LAG-3 and MHC-II molecules by binding to LAG-3. By blocking the binding of LAG-3 to MHC-II, ieramilimab restores the immune function of T cells and NK cells, including reducing T cell exhaustion, enhancing cytokine production, and increasing cytotoxicity. Ieramilimab also increases the infiltration of cytotoxic T lymphocytes into tumor tissue, reduces the baseline density of regulatory T cells, and improves the tumor immune microenvironment. Ieramilimab is being studied for use in the treatment of various malignant tumors. |
| Synonyms | NVP-LAG525, NVPLAG525, LAG525, LA525, IMP701, IM701 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | LAG3/CD223 |
| Molecular Weight | 146.51 kDa |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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