SLAMF6 Protein, Human, Recombinant (His)

Catalog No. TMPY-01914 Copy Product Info

SLAMF6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.3 kDa and the accession number is Q96DU3-1.

SLAMF6 Protein, Human, Recombinant (His)

Catalog No. TMPY-01914

Copy Product Info

SLAMF6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.3 kDa and the accession number is Q96DU3-1.

Pack Size	Price	USA Stock	Global Stock
5 μg	$68	7-10 days	7-10 days
10 μg	$108	7-10 days	7-10 days
20 μg	$178	7-10 days	7-10 days
50 μg	$359	7-10 days	7-10 days
100 μg	$696	7-10 days	7-10 days
200 μg	$1,060	7-10 days	7-10 days
500 μg	$2,230	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Biological Activity	Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.
Description	SLAMF6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.3 kDa and the accession number is Q96DU3-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q96DU3-1
Synonyms	SLAM family member 6,SF2000,NTB-A,NTBA,Ly108,KALIb,KALI,CD352
Construction	A DNA sequence encoding the human SLAMF6 (Q96DU3-1) extracellular domain (Met 1-Met 226) was expressed, with a polyhistidine tag at the C-terminus. Predicted N terminal: Gln 22
Protein Purity	> 90 % as determined by SDS-PAGE
Molecular Weight	24.3 kDa (predicted); 38-40 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein that belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly18 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.