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DBCO-PEG2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation, and enables selective protein degradation via the ubiquitin-proteasome system within cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $42 | 5 days | |
5 mg | $65 | Backorder |
Description | DBCO-PEG2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation, and enables selective protein degradation via the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two distinct ligands linked together: one targets an E3 ubiquitin ligase, while the other binds to a specific protein, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Molecular Weight | 464.51 |
Formula | C26H28N2O6 |
Cas No. | 2304558-25-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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