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M77976

Name: M77976
Brand: TargetMol
SKU: T15944
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15944Cas No. 394237-61-7

M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.

M77976

🥰Excellent

Purity: 99.43%

Catalog No. T15944Cas No. 394237-61-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$438	In Stock	In Stock
100 mg	$689	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.43%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.
Targets&IC50	PDK4:648 μM
In vitro	Binding to the ATP-binding pocket of PDK4, M77976 induces local conformational changes, resulting in complete disordering of the ATP lid[1]. M77976 engages in hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306, and Thr358 of PDK4[1].

Chemical Properties

Molecular Weight	296.32
Formula	C₁₇H₁₆N₂O₃
Cas No.	394237-61-7
Smiles	COc1ccc(cc1)-c1c(C)[nH]nc1-c1ccc(O)cc1O
Relative Density.	1.295 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (337.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3747 mL	16.8737 mL	33.7473 mL	168.7365 mL
5 mM	0.6749 mL	3.3747 mL	6.7495 mL	33.7473 mL
10 mM	0.3375 mL	1.6874 mL	3.3747 mL	16.8737 mL
20 mM	0.1687 mL	0.8437 mL	1.6874 mL	8.4368 mL
50 mM	0.0675 mL	0.3375 mL	0.6749 mL	3.3747 mL
100 mM	0.0337 mL	0.1687 mL	0.3375 mL	1.6874 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc