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Pifithrin-α, p-Nitro, Cyclic

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Catalog No. T12472Cas No. 60477-38-5
Alias PFN-α

Pifithrin-α, p-Nitro, Cyclic (PFN-α) is a cell-permeable, active-form inhibitor of p53.

Pifithrin-α, p-Nitro, Cyclic

Pifithrin-α, p-Nitro, Cyclic

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Purity: 99.43%
Catalog No. T12472Alias PFN-αCas No. 60477-38-5
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is a cell-permeable, active-form inhibitor of p53.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$34In StockIn Stock
2 mg$48In StockIn Stock
5 mg$80In StockIn Stock
10 mg$128In StockIn Stock
25 mg$263In StockIn Stock
50 mg$428In StockIn Stock
100 mg$639In StockIn Stock
1 mL x 10 mM (in DMSO)$79In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.43%
Appearance:Solid
Color:Yellow
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COA HPLC HNMR LCMS

Product Introduction

Bioactivity
Description
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is a cell-permeable, active-form inhibitor of p53.
In vitro
Pifithrin-α, p-Nitro, Cyclic (PFN-α) significantly inhibits p53-induced cell death and p21/WAF1 expression in cortical neurons exposed to etoposide, requiring concentrations an order of magnitude lower than PFT-α[1].
In vivo
Intraocular administration of pifithrin-α at a concentration of 6 µM modestly enhances the survival of retinal ganglion cells (RGC), while it remains ineffective at 0.06 µM. Despite the observed in vitro benefits, pifithrin-α, p-Nitro, Cyclic (PFN-α) demonstrates no in vivo efficacy, even at the 6 µM concentration. Furthermore, pifithrin-α, p-Nitro, Cyclic exhibits a half-life (t1/2) of 6 hours under biological conditions[1].
SynonymsPFN-α
Chemical Properties
Molecular Weight299.35
FormulaC15H13N3O2S
Cas No.60477-38-5
Smiles[O-][N+](=O)C1=CC=C(C=C1)C1=CN2C(SC3=C2CCCC3)=N1
Relative Density.1.53 g/cm3 (Predicted)
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 5 mg/mL (16.7 mM), Sonication is recommended.
DMF: 12.5 mg/mL (41.76 mM), Sonication is recommended.
Solution Preparation Table
DMSO/DMF
1mg5mg10mg50mg
1 mM3.3406 mL16.7029 mL33.4057 mL167.0286 mL
5 mM0.6681 mL3.3406 mL6.6811 mL33.4057 mL
10 mM0.3341 mL1.6703 mL3.3406 mL16.7029 mL
DMF
1mg5mg10mg50mg
20 mM0.1670 mL0.8351 mL1.6703 mL8.3514 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

WAF1posttranscriptionalPifithrin-α, p-Nitro, CyclicPifithrinα, pNitro, CyclicPifithrin-alpha, p-Nitro, CyclicPifithrin-a, p-Nitro, CyclicPifithrin α, p Nitro, CyclicPFN-alphaPFN-ap53-triggeredP53p21neuronsMDM-2/p53Inhibitorinhibitexpressiondeathcorticalcell
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