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Zinc Protoporphyrin

Name: Zinc Protoporphyrin
Brand: TargetMol
SKU: T13396
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13396Cas No. 15442-64-5

Alias ZnPP, Zn(II)-protoporphyrin IX, Zinc Protoporphyrin-9

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active, competitive inhibitor of heme oxygenase-1 (HO-1) that markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 and exhibits anti-cancer activity.

Zinc Protoporphyrin

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Purity: 99.27%

Catalog No. T13396Alias ZnPP, Zn(II)-protoporphyrin IX, Zinc Protoporphyrin-9Cas No. 15442-64-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$108	In Stock	In Stock
50 mg	$158	-	In Stock
100 mg	$235	-	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.27%

Color:Red to Black

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Product Introduction

Bioactivity

Description	Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active, competitive inhibitor of heme oxygenase-1 (HO-1) that markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 and exhibits anti-cancer activity.
In vitro	Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) increased the proportion of late apoptosis and necrotic cells from 10.9% in the control group to 30.4% after 72 hours [3]. Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells[3]. Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle[3]. Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3[3].
In vivo	Zinc Protoporphyrin exhibits dose-dependent antitumor effects manifested by the retardation of tumor growth[3].
Synonyms	ZnPP, Zn(II)-protoporphyrin IX, Zinc Protoporphyrin-9

Chemical Properties

Molecular Weight	626.02
Formula	C₃₄H₃₂N₄O₄Zn
Cas No.	15442-64-5
Smiles	CC1=C(CCC(O)=O)C2=N\C\1=C/c1c(C=C)c(C)c3\C=C4/N=C(/C=c5/c(C)c(CCC(O)=O)\c(=C\2)n5[Zn]n13)C(C)=C4C=C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (79.87 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5974 mL	7.9870 mL	15.9739 mL	79.8697 mL
5 mM	0.3195 mL	1.5974 mL	3.1948 mL	15.9739 mL
10 mM	0.1597 mL	0.7987 mL	1.5974 mL	7.9870 mL
20 mM	0.0799 mL	0.3993 mL	0.7987 mL	3.9935 mL
50 mM	0.0319 mL	0.1597 mL	0.3195 mL	1.5974 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc