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Bimagrumab (Synonyms: LY-3985863, LY3985863, LY 3985863, BYM-338, BYM338, BYM 338, Anti-ACVR2B Reference A...)
Catalog No. T76860 Copy Product Info
Purity: 98%
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Bimagrumab (BYM338) is a human monoclonal antibody that binds to the activin type II receptor. Bimagrumab can be used to study diabetes and obesity.
Bimagrumab
Copy Product Info🥰Excellent
Catalog No. T76860
Synonyms LY-3985863, LY3985863, LY 3985863, BYM-338, BYM338, BYM 338, Anti-ACVR2B Reference Antibody
Bimagrumab (BYM338) is a human monoclonal antibody that binds to the activin type II receptor. Bimagrumab can be used to study diabetes and obesity.
Bimagrumab
Cas No. 1356922-05-8
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $263 | In Stock | In Stock | |
| 5 mg | $662 | In Stock | In Stock | |
| 10 mg | $1,060 | - | In Stock | |
| 25 mg | $1,570 | - | In Stock | |
| 50 mg | $2,120 | - | In Stock | |
| 100 mg | $2,860 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Chemical Properties
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| Description | Bimagrumab (BYM338) is a human monoclonal antibody that binds to the activin type II receptor. Bimagrumab can be used to study diabetes and obesity. |
| Targets&IC50 | ACVR2A:434 pM (Kd), ACVR2B:1.7 pM (Kd) |
| In vitro | b>METHODS: Bimagrumab (Anti-ACVR2B Reference Antibody) (1 pM-1 μM) was used to treat HEK293 cells and its potency in inhibiting ActRII ligand signaling was evaluated in a Smad2/3 CAGA-luciferase reporter assay. RESULTS: Bimagrumab (Anti-ACVR2B Reference Antibody) showed similar dose-dependent inhibition of activin A-induced luciferase with an IC50 value of 343 ± 97 pM. [1] |
| In vivo | b>METHODS: Bimagrumab (Anti-ACVR2B Reference Antibody) (6, 20 mg/kg, subcutaneous injection) was used to treat mice and body weight was measured weekly to study its use in naive mice. RESULTS: Bimagrumab promoted weight gain and skeletal muscle hypertrophy in all examined mouse muscles, including slow, fast, and mixed muscles. [1] |
| Synonyms | LY-3985863, LY3985863, LY 3985863, BYM-338, BYM338, BYM 338, Anti-ACVR2B Reference Antibody |
| Reactivity | Human |
| Verified Activity | Immobilized Human ACVR2B Protein (aa 19-137, His) at 2 μg/mL (30 μL/well) can bind Bimagrumab. The EC50 is 0.005171 μg/mL  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ACVR2B |
| Molecular Weight | 142.73 kDa |
| Cas No. | 1356922-05-8 |
| Isotype | Human IgG1 lambda C2 |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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