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Bergamottin

Name: Bergamottin
Brand: TargetMol
SKU: T5S0669
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0669Cas No. 7380-40-7

Alias Bergaptin, Bergamotine, 5-Geranoxypsoralen

1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A^ydiabetic mice.

Bergamottin

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Purity: 99.99%

Catalog No. T5S0669Alias Bergaptin, Bergamotine, 5-GeranoxypsoralenCas No. 7380-40-7

1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A^ydiabetic mice.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$155	In Stock	In Stock
25 mg	$322	In Stock	In Stock
50 mg	$478	-	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bergamottin AI Summary

Bergamottin demonstrates a broad spectrum of bioactivities across various molecular targets and cell lines. It inhibits the enzyme CYP3A4 with an IC50 value of 2420.0 nM, as measured by a fluorescence microplate reader assay. It acts as an agonist of the Thyroid Stimulating Hormone Receptor, increases intracellular cAMP levels in HEK 293 cells, and inhibits Tyrosyl-DNA Phosphodiesterase (TDP1). Additionally, it inhibits and serves as a substrate for multiple Cytochrome P450 enzymes, including 2C19, 2D6, 2C9, 2B6, 2E1, 3A4, 3A5 in humans, and certain enzymes in other species, with varied Ki and Kinact values indicating its potent interaction with drug metabolism pathways. Bergamottin also shows inhibitory effects on the recombinant human BACE1 enzyme (IC50 of 32200.0 nM and Ki of 34800.0 nM), uptake of Fexofenadine in Oatp3-expressing HeLa cells (22.0%), and Estrone-3-sulfate via OATP2B1 in HEK293 cells (40.0%). It enhances Vinblastine uptake in Caco-2 cells with an EC200 of 0.035 uM and competitively inhibits CYP1B1 with a Ki value of 587,000.0 nM in yeast microsomes. Notably, Bergamottin exerts significant antiausteritic activity against human pancreatic cancer cells (PSN1, MIAPaCa2, and PANC1) in nutrient-deprived conditions, with PC50 values ranging from 2.2 uM to 9.4 uM, induces cell death and inhibits migration and colony formation in PANC1 cells. Lastly, it effectively inhibits LuxN quorum sensing signaling in Vibrio harveyi BB886 with a 96.7% decrease in N-acylhomoserine lactone (HAI-1) activity. Overall, Bergamottin exhibits multifaceted bioactivity, impacting both agonistic and inhibitory pathways across a wide array of biological systems..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A^ydiabetic mice.
Targets&IC50	CYP1A2:5.077 μM, CYP2B2:4.535 μM, CYP2B1:9.495 μM, CYP1A1:10.703 nM(Ki), CYP1A1:0.192 μM
Synonyms	Bergaptin, Bergamotine, 5-Geranoxypsoralen

Chemical Properties

Molecular Weight	338.40
Formula	C₂₁H₂₂O₄
Cas No.	7380-40-7
Smiles	CC(C)=CCC\C(C)=C\COc1c2ccoc2cc2oc(=O)ccc12
Relative Density.	1.153g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65.00 mg/mL (192.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9551 mL	14.7754 mL	29.5508 mL	147.7541 mL
5 mM	0.5910 mL	2.9551 mL	5.9102 mL	29.5508 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL	14.7754 mL
20 mM	0.1478 mL	0.7388 mL	1.4775 mL	7.3877 mL
50 mM	0.0591 mL	0.2955 mL	0.5910 mL	2.9551 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	1.4775 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc