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Doxofylline

Name: Doxofylline
Brand: TargetMol
SKU: T0480
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0480Cas No. 69975-86-6

Alias Doxophylline

Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies.

Doxofylline

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Purity: 99.958%

Catalog No. T0480Alias DoxophyllineCas No. 69975-86-6

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	In Stock
100 mg	$48	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.958%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies.
In vitro	At an effective therapeutic dose, Doxofylline exhibits a less pronounced cardiac stimulant effect compared to theophylline. As a result, Doxofylline does not significantly increase heart rate, nor does it induce arrhythmias. Administration of 30 mg/kg of Doxofylline results in an increase of 13 beats/min in the heart rate of anesthetized cats.
In vivo	Doxofylline exhibits the activity of a phosphodiesterase (PDE) inhibitor and enhances the levels of cyclic adenosine monophosphate (cAMP), thus it is utilized in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Compared to theophylline, doxofylline significantly reduces the affinity for adenosine A1 and A2 receptors, which may contribute to its improved safety profile. Additionally, doxofylline does not interfere with calcium ion influx nor antagonize calcium channel blockers. In terms of inhibitory potency, the half-maximal effective concentration (EC50) of doxofylline against adenosine-induced tracheal smooth muscle relaxation is 15-fold higher than that of aminophylline, and it also displays a 15-fold higher EC50 in reducing the negative inotropic effect of adenosine on guinea pig atria than aminophylline.
Synonyms	Doxophylline

Chemical Properties

Molecular Weight	266.25
Formula	C₁₁H₁₄N₄O₄
Cas No.	69975-86-6
Smiles	Cn1c2ncn(CC3OCCO3)c2c(=O)n(C)c1=O
Relative Density.	1.59 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (187.79 mM), Sonication is recommended.

H2O: 22 mg/mL (82.63 mM), Sonication is recommended.

Ethanol: 2 mg/mL (7.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7559 mL	18.7793 mL	37.5587 mL	187.7934 mL
5 mM	0.7512 mL	3.7559 mL	7.5117 mL	37.5587 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3756 mL	1.8779 mL	3.7559 mL	18.7793 mL
20 mM	0.1878 mL	0.9390 mL	1.8779 mL	9.3897 mL
50 mM	0.0751 mL	0.3756 mL	0.7512 mL	3.7559 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0376 mL	0.1878 mL	0.3756 mL	1.8779 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc