Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

BCRP

The breast cancer resistance protein (BCRP), this protein functions as a xenobiotic transporter which may play a role in multi-drug resistance to chemotherapeutic agents including mitoxantrone and camptothecin analogues.

Elacridar
T2657143664-11-3
Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.
  • $35
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Ko 143
TQ0186461054-93-3
Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
  • $39
In Stock
Size
QTY
TargetMol | Citations Cited
Moxidectin
T1157113507-06-5
Moxidectin (CL301423) is an anthelmintic drug which kills parasitic worms, and is used for the prevention and control of heartworm and intestinal worms. It can be found in treatments prescribed for animals such as dogs, cats, horses, cattle and sheep. Application methods for moxidectin vary by treatment, and include oral, topical, and injectable solutions. Cydectin Pour On is a trade name for a formulation for use on cattle and red deer.
  • $40
In Stock
Size
QTY
Zamicastat
T133831080028-80-3
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH) and a concentration-dependent dual inhibitor of P-gp and BCRP, with IC50 values of 73.8 μM and 17.0 μM, respectively.
  • $88
In Stock
Size
QTY
CCTA-1523
T95871616271-41-0In house
CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.
  • $89
In Stock
Size
QTY
YHO-13351 free base
T13365912288-64-3In house
YHO-13351 free base, the water-soluble prodrug of YHO-13177, is an inhibitor of BCRP (breast cancer resistance protein).
  • $30
In Stock
Size
QTY
Brevianamide F
T320838136-70-8
Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), is a naturally occurring 2,5-diketopiperazine with notable breast cancer resistance protein inhibitory activity.
  • $35
In Stock
Size
QTY
YHO-13177
T4595912287-56-0
YHO-13177 is a potent and specific inhibitor of BCRP, which enhances the cytotoxicity of SN-38 in cancer cells without affecting P-glycoprotein–mediated paclitaxel resistance in [MDR1]-transduced human leukemia [K562] cells.
  • $33
In Stock
Size
QTY
Triclabendazole sulfoxide
T38400100648-13-3
Triclabendazole sulfoxide (TCBZ-SO), a primary plasma metabolite of Triclabendazole, inhibits the membrane transporter ABCG2/BCRP and demonstrates anti-parasite effects.
  • $38
In Stock
Size
QTY
YHO-13351
T133661346753-00-1
YHO-13351 is an ABCG2 inhibitor, an acrylonitrile derivative, that induces sensitization of cancer stem initiating-like side population cells to irinotecan.GSK1702934A can be used to study diabetes.
  • $30
In Stock
Size
QTY
PCI 29732
T4337330786-25-9
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
  • $34
In Stock
Size
QTY
KS176
T35811253452-78-6
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, exhibiting no inhibitory activity against P-gp or MRP1.
  • $29
In Stock
Size
QTY
GS-9191 PM
T67821 In house
GS-9191 PM is a novel antitumorviral compound, a bis-amide prodrug of the nucleotide analog 9-(2-phosphonomethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cPrPMEDAP).GS-9191 PM is a potent inhibitor of MDR1 and BCRP.GS-9191 PM exhibits both antiproliferative and antitumorviral activities.
  • $58
In Stock
Size
QTY
TargetMol | Inhibitor Sale
CP-100356 hydrochloride
T22680142715-48-8
CP-100356 hydrochloride is an orally active, low micromolar dual inhibitor of MDR1 (P-gp) and BCRP, a nucleotide-derived substrate analogue that inhibits MDR1-mediated Calcein-AM and BCRP-mediated Prazosin transporters. Additionally, CP-100356 inhibits OATP1B1 and induces stomatal opening in the dark.
  • $69
In Stock
Size
QTY
6,8-Diprenylnaringenin
TN315068236-11-3
6,8-Diprenylnaringenin (Senegalensin) is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estrogenicity.
  • $417
Backorder
Size
QTY
5,7,3'-Trihydroxy-4'-methoxy-8-prenylflavanone
TN30861268140-15-3
5,7,3'-Trihydroxy-4'-methoxy-8-prenylflavanone, a flavonoid, is found in the bark of *Azadirachta indica*.
  • $301
Backorder
Size
QTY
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
TN712419056-75-8
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.
  • $195
Backorder
Size
QTY
Fumitremorgin C
T15355118974-02-0
Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2 BRCP.
  • $530
35 days
Size
QTY
Butein tetramethyl ether
T204268155048-06-9
Butein tetramethyl ether (Compound 20) is a potent and selective inhibitor of breast cancer resistance protein ATP-binding cassette sub-family G member 2 (BCRP ABCG2). It inhibits MCF-7 MX and MDCKBCRP cells with IC50 values of 2.2 μM and 1.03 μM, respectively. Butein tetramethyl ether holds potential for cancer research.
  • Inquiry Price
10-14 weeks
Size
QTY
ABCG2-IN-2
T795142559759-59-8
ABCG2-IN-2 is a potent inhibitor of ABCG2, showing favorable oral pharmacokinetic profiles in mice, and is applicable for investigating tumor multidrug resistance (MDR) and erythropoietic protoporphyria (EPP) [1].
  • $1,520
6-8 weeks
Size
QTY
Vedroprevir
T350431098189-15-1
Vedroprevir, also known as GS9451, is a selective hepatitis C virus (HCV) NS3 protease inhibitor in the development of the treatment of genotype 1 (GT1) HCV infection.
  • Inquiry Price
Size
QTY
CAY10719
T376851942919-63-2
CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 μM) with little activity at ABCG1. It has been shown to reverse the ABCG2-mediated resistance toward SN 38 and to inhibit ATPase activity.
  • $297
35 days
Size
QTY
BCRP-IN-2
T2034992953730-35-1
BCRP-IN-2 is a compound with BCRP inhibitory activity, exhibiting enhanced inhibition of BCRP upon UV activation. It serves as a valuable probe for studying interactions between quinazoline amine derivatives and BCRP, and it stimulates ATP hydrolysis of the BCRP transporter, leading to increased mitoxantrone accumulation in BCRP-overexpressing H460 MX20 cells.
  • Inquiry Price
10-14 weeks
Size
QTY
INCB-056868
TXB-006792252320-89-9
INCB-056868 is the metabolite M11 of Epacadostat. It serves as a substrate for BCRP and holds potential for use in the study of metabolic diseases.
  • Inquiry Price
10-14 weeks
Size
QTY