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TargetMol | Compound Library

FDA-Approved Drug Library

Catalog No. L4200

All compounds in FDA approved drug library have well-characterized biological activity, clear targets, safety, and bioavailability – properties which could dramatically accelerate drug development and optimization. It is an effective and ideal tool for drug repurposing and cell differentiation induction. Detailed information on each compound in this library can help scientists quickly finish drug screening or make quick judgement on cell differentiation mechanism, and create conditions for further investigation on the mechanism of action.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L4200

FDA-Approved Drug Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 1845 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS);
  • Bioactivity and safety confirmed by pre-clinical research evidence and clinical trials;
  • An effective tool for discovering new with old drugs and new drug target identification;
  • Covers various research areas: oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc
  • Structurally diverse, medicinally active, and cell permeable;
  • Rich documentation with structure, target, IC50 value and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity.

Advantages Introduction Advantages Introduction

High-Standard Entry Criteria

TargetMol’s FDA-Approved Drug Library is curated with stringent entry criteria to ensure that every compound in the collection is structurally well-defined and of high purity. Multiple analytical techniques—such as NMR, HPLC, and LCMS—are employed to verify compound integrity. Through a rigorous multi-step screening process, we exclude compounds with ambiguous structures (e.g., mixtures and polymers) and non-active agents such as sunscreens, contrast agents, and inorganic compounds. This helps reduce ineffective screening efforts and unnecessary resource consumption. This library includes only FDA-approved small molecule drugs. For compounds approved by other regulatory agencies (such as PMDA, EMA, and NMPA), please refer to our L1000 Approved Drug Library,L1020 EMA Approved Drug Library L1000 Approved Drug Library and L1020 EMA Approved Drug Library.

Significant Structural Diversity

TargetMol’s FDA-Approved Drug Library exhibits remarkable structural diversity, offering substantial advantages in drug discovery. Based on MACCS fingerprint analysis, the library can be categorized into 1,392 classes, effectively covering a broad chemical space. The library includes a wide variety of compounds, ranging from simple to highly complex chemical structures. This diversity provides a wealth of possibilities for identifying lead compounds with high affinity and specificity for target proteins, significantly advancing drug innovation.

 FDA-Approved Drug Library
Library Diversity Analysis

Diverse Compound Selection

TargetMol's FDA-Approved Drug Library features a highly diverse collection of compounds, both in terms of chemical structure and biological function. The library includes a broad range of key signaling pathway modulators, such as kinase inhibitors, G protein-coupled receptor (GPCR) ligands, ion channel modulators, and epigenetic regulators. These compounds cover a wide array of disease areas including cancer, immunological disorders, neurological diseases, metabolic conditions, and infectious diseases. In addition, the FDA-approved drugs span multiple administration routes, including but not limited to oral, injectable, inhalation, and topical applications. This comprehensive chemical space enables researchers to explore novel therapeutic approaches and accelerate the discovery of innovative medicines.

 FDA-Approved Drug Library
Drug and Administration Route
 FDA-Approved Drug Library
Pathways Composition
 FDA-Approved Drug Library
Disease Types

Regular Updates to Compound Libraries

TargetMol ensures compound libraries stay at the forefront of science by regularly updating our database to include the latest approved and marketed drugs.

Flexible Packaging Options

TargetMol provides a variety of standard packaging sizes (such as 30 μL, 50 μL, 100 μL, 250 μL, and 1 mg), and offer customized packaging solutions tailored to specific needs.

Personalized Custom Services

TargetMol offers fully customized screening services, including the design and synthesis of compound libraries. Our highly flexible service is designed to efficiently meet the unique needs of scientists and researchers.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Antibacterial
Autophagy
Antibiotic
Apoptosis
Adrenergic Receptor
Endogenous Metabolite
5-HT Receptor
AChR
Histamine Receptor
Dopamine Receptor
HIV Protease
Sodium Channel
Parasite
COX
Antifungal
Glucocorticoid Receptor
Potassium Channel
DNA/RNA Synthesis
Estrogen/progestogen Receptor
Calcium Channel
Cytochromes P450
Topoisomerase
Ferroptosis
RAAS
SARS-CoV
VEGFR
Estrogen Receptor/ERR
Serotonin Transporter
Mitophagy
PDE
ribosome
c-Kit
Microtubule Associated
Dehydrogenase
Norepinephrine
GABA Receptor
Reverse Transcriptase
HCV Protease
Nucleoside Antimetabolite/Analog
EGFR
Antifection
PDGFR
Progesterone Receptor
PPAR
HSV
Proton pump
Androgen Receptor
Carbonic Anhydrase
DNA Alkylator/Crosslinker
ATPase
HBV
Reactive Oxygen Species
JAK
Prostaglandin Receptor
Influenza Virus
FLT
HMG-CoA Reductase
Src
MAO
Cholinesterase (ChE)
FGFR
Proteasome
Adenosine Receptor
Bcr-Abl
MRP
NF-κB
Thrombin
Phosphatase
Raf
Tyrosine Kinases
ROS
HDAC
c-RET
DHFR
c-Met/HGFR
Thyroid hormone receptor(THR)
Transferase
Virus Protease
PARP
Antifolate
TRP/TRPV Channel
Opioid Receptor
MMP
ALK
Monoamine Oxidase
iGluR
Drug Metabolite
SGLT
HIF/HIF Prolyl-Hydroxylase
PI3K
ABC Transporter
P-gp
Endothelin Receptor
NO Synthase
Retinoid Receptor
STAT
P2Y Receptor
Factor Xa
DNA gyrase
CDK
DPP-4
DNA Alkylation
GluR
CaMK
mTOR
MEK
DNA Methyltransferase
LPL Receptor
NMDAR
PKC
Guanylate cyclase
IL Receptor
Lipoxygenase
TLR
Trk receptor
AMPK
TNF
Phospholipase
HIF
S1P Receptor
ADC Cytotoxin
Histone Methyltransferase
NADPH
Integrin
GNRH Receptor
ROCK
Monoamine Transporter
Interleukin
HSP
Hedgehog/Smoothened
Antiviral
CFTR
Nrf2
Neurokinin receptor
TAM Receptor
ROS Kinase
HER
GPCR
Cell wall
Glutathione Peroxidase
Annexin A
FXR
ERK
Vasopressin Receptor
DNA
GPCR19
Molecular Glues
Isocitrate Dehydrogenase (IDH)
AhR
Ligand for E3 Ligase
Aromatase
Hydroxylase
NOS
Reductase
Histone Demethylase
LDL
Mitochondrial Metabolism
Cysteine Protease
Aryl Hydrocarbon Receptor
MT Receptor
Smo
Fatty Acid Synthase
Akt
Bcl-2 Family
Decarboxylase
PAK
IGF-1R
Neprilysin
c-Fms
CGRP Receptor
Complement System
Sigma receptor
Chloride channel
CRM1
Arginase
GSK-3
Melatonin Receptor
MicroRNA
Amino Acids and Derivatives
Ligands for Target Protein for PROTAC
Antioxidant
CETP
CaSR
Caspase
IRE1
UGT
Rho
Leukotriene Receptor
CSF-1R
Gamma-secretase
Na-K-Cl cotransporter
CXCR
Xanthine Oxidase
Thrombopoietin Receptor
PGE Synthase
Beta-Secretase
Glutathione reductase
Free radical scavengers
Integrase
CCR
OAT
Ephrin Receptor
GluCls
GST
Beta Amyloid
Protease-activated Receptor
RSV
Kras
Melanocortin Receptor
Oxytocin Receptor
Adenosine Deaminase
Gap Junction Protein
Syk
Ras
BTK
ROR
DNA-PK
JNK
gp120/CD4
TOPK
NPC1L1
Hydrogenase
RAR/RXR
p38 MAPK
YAP
IFNAR
Na+/Ca2+ Exchanger
VDA
PKA
Wnt/beta-catenin
Serine Protease
IAP
Myosin
Adiponectin Receptor
Cholecystokinin Receptor
MTH1
GRK
Glucagon Receptor
P2X Receptor
GlyT
Glucosidase
HCN Channel
ACK1
Angiotensin-converting Enzyme (ACE)
Chk
Somatostatin
Epigenetic Reader Domain
DUB
TGF-beta/Smad
ATP Citrate Lyase
STING
PROTAC Linker
FAAH
Telomerase
Lipid
MAPK
Pyroptosis
IκB/IKK
PDK
PKM
CRFR
CRISPR/Cas9
Aquaporin
PLK
Platelet aggregation
Anti-infection
NADPH-oxidase
Tyrosinase
NOD-like Receptor (NLR)
Vitamin

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