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FDA-Approved Drug Library

Catalog No. L4200
  Library Compound List   Excel SDF

All compounds in FDA approved drug library have well-characterized biological activity, clear targets, safety, and bioavailability – properties which could dramatically accelerate drug development and optimization. It is an effective and ideal tool for drug repurposing and cell differentiation induction. Detailed information on each compound in this library can help scientists quickly finish drug screening or make quick judgement on cell differentiation mechanism, and create conditions for further investigation on the mechanism of action.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
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Product Description

  • A unique collection of 1729 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS);
  • Bioactivity and safety confirmed by pre-clinical research evidence and clinical trials;
  • An effective tool for discovering new with old drugs and new drug target identification;
  • Covers various research areas: oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc
  • Structurally diverse, medicinally active, and cell permeable;
  • Rich documentation with structure, target, IC50 value and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L4200)

Publications Cited TargetMol Libraries

1. Nature Biotechnology. 2021, 39(11): 1444-1452. 2. ACS Central Science. 2023. 3. Nature Communications. 2023, 14(1): 2756.. 4. Nature Communications. 2023, 14(1): 1020.. 5. Blood. 2021, 137(11): 1478-1490. 6. Advanced Science. 2021: 2101957. 7. Protein & Cell. 2021: 1-19.. 8. Bone Research. 2023, 11(1): 54. 9. Journal of Experimental & Clinical Cancer Research. 2023, 42(1): 1-27..
10. Pharmacology & Therapeutics. (2021): 107930. 11. Microbial Biotechnology. 2022, 15(2): 482-498. 12. Journal of Translational Medicine. 2022, 20(1): 1-11.. 13. Cancer Research. 2020. 14. Neuropsychopharmacology. 2022: 1-9. 15. Theranostics. 2020, 10(13): 5749-5762. 16. PLoS Biology. 2021, 19(10): e3001425. 17. Journal of Medicinal Chemistry. 2023. 18. Immunology. 2023;1–10.. 19. Microbiology Spectrum. 2022: e00884-22. 20. Elife. 2021, 10: e65962. 21. Translational Research. 2022. 22. European Journal of Medicinal Chemistry. 2023: 116018.. 23. International Journal of Molecular Sciences. 2022, 23(19): 11250. 24. Fundamental Research. 2023. 25. Cell Death & Disease. 2020, 11(3): 1-12. 26. International Journal of Molecular Sciences. 2022, 23(7): 4050. 27. International Journal of Molecular Sciences. 2020. 28. Viruses. 2021 Jun 3;13(6):1061. 29. International Journal of Oncology. 2022, 60(6): 1-13. 30. Journal of Molecular Cell Biology. 2023: mjad056. 31. Journal of Virus Eradication. 2023: 100327.. 32. Frontiers in Immunology. 2020, 11. 33. Scientific Reports. 2022 Nov 2;12(1):18506. 34. Molecules. 2022, 27(15): 5000.. 35. Antimicrobial agents and chemotherapy. 2021, 65(4): e02577-20. 36. Antimicrobial Agents and Chemotherapy. 2020, 64(9). 37. CNS Oncology. 2020. 38. Viruses. 2023, 15(8): 1666.. 39. ACS Infectious Diseases. 2021 Aug 13;7(8):2337-2351. 40. Journal of virology. 2018, 92(20): e01018-18.. 41. Virologica Sinica. 2022. 42. Journal of Proteome Research. 2020. 43. Journal of Biological Chemistry. 2016 Apr;291(17): 9218-9232.. 44. Acta Pharmacologica Sinica, 2019, 40(12): 1568-1577. 45. Neoplasia. 2020, 22(4): 179-191. 46. Virology. 2022. 47. Molecular Informatics. 2022. 48. Journal of Biomolecular Structure and Dynamics. 2020: 1-16. 49. Journal of Clinical Medicine. 2020, 9(5): 1473. 50. RSC Advances. 2021, 11(4): 2158-2166. 51. Orthopaedic Surgery. 2023. 52. Interdisciplinary Sciences: Computational Life Sciences, 2020, 12: 368-376. 53. Hollis R L, Elliott R, Dawson J C, et al.High throughput screening identifies dasatinib as synergistic with trametinib in low grade serous ovarian carcinoma.Gynecologic Oncology.2024, 186: 42-52. 54. Dou X, Huo T, Liu Y, et al.Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation.European Journal of Medicinal Chemistry.2024: 116323. 55. bioRxiv. 2023: 2023.05. 24.542186.. 56. SSRN. 2023. 57. bioRxiv. 2021. 58. AIP Publishing LLC. 2021, 2370(1): 070005. 59. researchsquare. 2022. 60. Chemrxiv. 2020. 61. Cell Stem Cell. 2022 Apr 29(4) 545–558. 62. Science Bulletin. 2022. 63. Science Translational Medicine. 2022, 14(656): eabn3231. 64. Science Advances. 2023, 9(9): eade3760. 65. Nature. 2020, 582: 289-293. 66. Nature Communications. 2022, 13(1): 1-15.. 67. Nucleic Acids Research. 2021. 68. Nature Communications. 2023, 14(1): 7574. 69. Advanced Science. 2020, 7(16): 2000925. 70. Angewandte Chemie. 2021. 71. Acta Pharmaceutica Sinica B. 2022. 72. Protein & Cell. 2021, 12(11): 877-888. 73. Nature Communications. 2021, 12(1): 1-12. 74. Journal of Cell Biology. 2022, 221(5): e202112024. 75. Liu T, Yue X, Chen X, et al.Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma.Cellular Oncology.2024: 1-18. 76. Fang Z Y, Zhang Z Y, Zheng Y D, et al.Repurposing cinacalcet suppresses multidrug-resistant Staphylococcus aureus by disruption of cell membrane and inhibits biofilm by targeting IcaR.Journal of Antimicrobial Chemotherapy.2024: dkae051. 77. Cao Z, Hou Y, Zhao Z, et al.Reactivating Hippo by Drug Compounds to Suppress Gastric Cancer and Enhance Chemotherapy Sensitivity.Journal of Biological Chemistry.2024: 107311. 78. Tao X, Cheng M, Huang X, et al.Dabrafenib Alleviates Hepatotoxicity Caused by Lenvatinib via Inhibiting the Death Receptor Signaling Pathway.Toxicology Letters.2024
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Library Composition

Antibacterial (259)
Antibiotic (253)
Autophagy (250)
Apoptosis (166)
Endogenous Metabolite (130)
Adrenergic Receptor (116)
5-HT Receptor (109)
AChR (81)
Histamine Receptor (75)
Dopamine Receptor (70)
HIV Protease (70)
COX (59)
Sodium Channel (57)
Parasite (56)
Antifungal (54)
DNA/RNA Synthesis (54)
Potassium Channel (48)
Glucocorticoid Receptor (43)
Estrogen/progestogen Receptor (38)
Calcium Channel (36)
Topoisomerase (34)
P450 (34)
Ferroptosis (30)
SARS-CoV (30)
RAAS (27)
Serotonin Transporter (27)
ribosome (27)
VEGFR (25)
c-Kit (25)
PDE (24)
Dehydrogenase (24)
Mitophagy (24)
Microtubule Associated (23)
Nucleoside Antimetabolite/Analog (22)
Reverse Transcriptase (22)
Antifection (22)
Norepinephrine (21)
HCV Protease (21)
Estrogen Receptor/ERR (20)
GABA Receptor (20)
HSV (20)
PDGFR (20)
Progesterone Receptor (20)
EGFR (17)
PPAR (17)
Proton pump (17)
Reactive Oxygen Species (17)
Influenza Virus (16)
Androgen Receptor (16)
Prostaglandin Receptor (15)
ATPase (15)
FLT (15)
HBV (15)
DNA Alkylator/Crosslinker (14)
Carbonic Anhydrase (14)
JAK (14)
FGFR (13)
MAO (13)
Thrombin (13)
NF-κB (12)
Proteasome (12)
Adenosine Receptor (12)
AChE (12)
Src (12)
Raf (11)
Virus Protease (11)
c-Met/HGFR (11)
ROS (11)
Bcr-Abl (11)
MRP (10)
Transferase (10)
Tyrosine Kinases (10)
DHFR (10)
ALK (10)
Monoamine Oxidase (10)
iGluR (9)
Drug Metabolite (9)
SGLT (9)
HDAC (9)
c-RET (9)
NO Synthase (9)
HMG-CoA Reductase (9)
PI3K (9)
Antifolate (9)
Phosphatase (9)
CDK (8)
P-gp (8)
MMP (8)
Opioid Receptor (8)
mTOR (8)
Thyroid hormone receptor(THR) (8)
GluR (8)
ABC (8)
TRP/TRPV Channel (8)
PARP (8)
Retinoid Receptor (8)
P2Y Receptor (7)
Phospholipase (7)
DNA Methyltransferase (7)
MEK (7)
CaMK (7)
PKC (7)
HIF/HIF Prolyl-Hydroxylase (7)
DPP-4 (7)
Factor Xa (7)
DNA gyrase (7)
NMDAR (6)
Endothelin Receptor (6)
DNA Alkylation (6)
CAT (6)
Trk receptor (6)
STAT (6)
TAM Receptor (6)
S1P Receptor (6)
LPL Receptor (6)
Guanylate cyclase (5)
ROS Kinase (5)
Histone Methyltransferase (5)
IL Receptor (5)
Ras (5)
Neurokinin receptor (5)
TLR (5)
TNF (5)
CFTR (5)
Monoamine Transporter (5)
Hedgehog/Smoothened (5)
GPR (5)
ERK (5)
Nrf2 (5)
Lipoxygenase (5)
Antiviral (4)
AhR (4)
HIF (4)
AMPK (4)
HER (4)
BTK (4)
Integrin (4)
Amino Acids and Derivatives (4)
Annexin A (4)
NADPH (4)
Glutathione Peroxidase (4)
FXR (4)
PAK (3)
GST (3)
LDL (3)
Gamma-secretase (3)
GPCR19 (3)
Decarboxylase (3)
Neprilysin (3)
BCL (3)
Ligand for E3 Ligase (3)
Aryl Hydrocarbon Receptor (3)
ROCK (3)
Akt (3)
Cysteine Protease (3)
GNRH Receptor (3)
Hydroxylase (3)
Histone Demethylase (3)
Cell wall (3)
Reductase (3)
NOS (3)
MT Receptor (3)
Fatty Acid Synthase (3)
DNA (3)
Mitochondrial Metabolism (3)
Molecular Glues (3)
Isocitrate Dehydrogenase (IDH) (3)
IGF-1R (3)
Smo (3)
GSK-3 (2)
Melatonin Receptor (2)
CaSR (2)
Melanocortin Receptor (2)
Interleukin (2)
CGRP Receptor (2)
c-Fms (2)
Xanthine Oxidase (2)
Leukotriene Receptor (2)
Caspase (2)
Adenosine deaminase (2)
P2X Receptor (2)
Thrombopoietin Receptor (2)
Complement System (2)
CETP (2)
Gap Junction Protein (2)
Syk (2)
CCR (2)
Antioxidant (2)
Arginase (2)
Sigma receptor (2)
Ligands for Target Protein for PROTAC (2)
Integrase (2)
Protease-activated Receptor (2)
CRM1 (2)
Chloride channel (2)
PKM (2)
Beta Amyloid (2)
Rho (2)
Beta-Secretase (2)
RSV (2)
UGT (2)
Glutathione reductase (2)
IRE1 (2)
Na-K-Cl cotransporter (2)
GluCls (2)
Lipid (2)
Ephrin Receptor (2)
PGE Synthase (2)
Free radical scavengers (2)
Epigenetic Reader Domain (1)
YAP (1)
NADPH-oxidase (1)
Anti-infection (1)
RAR/RXR  (1)
Vasopressin Receptor (1)
Platelet aggregation (1)
GlyT (1)
Glucagon Receptor (1)
Tyrosinase (1)
p38 MAPK (1)
ATP Citrate Lyase (1)
MAPK (1)
Phosphorylase (1)
PROTAC Linker (1)
DNA-PK (1)
ROR (1)
NOD-like Receptor (NLR) (1)
Hydrogenase (1)
NPC1L1 (1)
FAAH (1)
TGF-beta/Smad (1)
Telomerase (1)
CXCR (1)
JNK (1)
GRK (1)
STING (1)
CSF-1R (1)
Pyroptosis (1)
ACK (1)
IAP (1)
Myosin (1)
OX Receptor (1)
Somatostatin (1)
CRISPR/Cas9 (1)
Serine Protease (1)
Wnt/beta-catenin (1)
PKA (1)
Oxytocin Receptor (1)
Aquaporin (1)
DUB (1)
Glucosidase (1)
Adiponectin receptor (1)
Chk (1)
PLK (1)
HSP (1)
VDA (1)
TOPK (1)
Angiotensin-converting Enzyme (ACE) (1)
gp120/CD4 (1)
MTH1 (1)
Hexokinase (1)
OAT (1)
IκB/IKK (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
TargetMol