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TargetMol | Compound Library

FDA-Approved Drug Library

Catalog No. L4200

All compounds in FDA approved drug library have well-characterized biological activity, clear targets, safety, and bioavailability – properties which could dramatically accelerate drug development and optimization. It is an effective and ideal tool for drug repurposing and cell differentiation induction. Detailed information on each compound in this library can help scientists quickly finish drug screening or make quick judgement on cell differentiation mechanism, and create conditions for further investigation on the mechanism of action.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L4200

FDA-Approved Drug Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 1845 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS);
  • Bioactivity and safety confirmed by pre-clinical research evidence and clinical trials;
  • An effective tool for discovering new with old drugs and new drug target identification;
  • Covers various research areas: oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc
  • Structurally diverse, medicinally active, and cell permeable;
  • Rich documentation with structure, target, IC50 value and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity.

Advantages Introduction Advantages Introduction

High-Standard Entry Criteria

TargetMol’s FDA-Approved Drug Library is curated with stringent entry criteria to ensure that every compound in the collection is structurally well-defined and of high purity. Multiple analytical techniques—such as NMR, HPLC, and LCMS—are employed to verify compound integrity. Through a rigorous multi-step screening process, we exclude compounds with ambiguous structures (e.g., mixtures and polymers) and non-active agents such as sunscreens, contrast agents, and inorganic compounds. This helps reduce ineffective screening efforts and unnecessary resource consumption. This library includes only FDA-approved small molecule drugs. For compounds approved by other regulatory agencies (such as PMDA, EMA, and NMPA), please refer to our L1000 Approved Drug Library,L1020 EMA Approved Drug Library L1000 Approved Drug Library and L1020 EMA Approved Drug Library.

Significant Structural Diversity

TargetMol’s FDA-Approved Drug Library exhibits remarkable structural diversity, offering substantial advantages in drug discovery. Based on MACCS fingerprint analysis, the library can be categorized into 1,392 classes, effectively covering a broad chemical space. The library includes a wide variety of compounds, ranging from simple to highly complex chemical structures. This diversity provides a wealth of possibilities for identifying lead compounds with high affinity and specificity for target proteins, significantly advancing drug innovation.

 FDA-Approved Drug Library
Library Diversity Analysis

Diverse Compound Selection

TargetMol's FDA-Approved Drug Library features a highly diverse collection of compounds, both in terms of chemical structure and biological function. The library includes a broad range of key signaling pathway modulators, such as kinase inhibitors, G protein-coupled receptor (GPCR) ligands, ion channel modulators, and epigenetic regulators. These compounds cover a wide array of disease areas including cancer, immunological disorders, neurological diseases, metabolic conditions, and infectious diseases. In addition, the FDA-approved drugs span multiple administration routes, including but not limited to oral, injectable, inhalation, and topical applications. This comprehensive chemical space enables researchers to explore novel therapeutic approaches and accelerate the discovery of innovative medicines.

 FDA-Approved Drug Library
Drug and Administration Route
 FDA-Approved Drug Library
Pathways Composition
 FDA-Approved Drug Library
Disease Types

Regular Updates to Compound Libraries

TargetMol ensures compound libraries stay at the forefront of science by regularly updating our database to include the latest approved and marketed drugs.

Flexible Packaging Options

TargetMol provides a variety of standard packaging sizes (such as 30 μL, 50 μL, 100 μL, 250 μL, and 1 mg), and offer customized packaging solutions tailored to specific needs.

Personalized Custom Services

TargetMol offers fully customized screening services, including the design and synthesis of compound libraries. Our highly flexible service is designed to efficiently meet the unique needs of scientists and researchers.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Antibacterial
Autophagy
Antibiotic
Apoptosis
Endogenous Metabolite
Adrenergic Receptor
5-HT Receptor
AChR
Histamine Receptor
Dopamine Receptor
HIV Protease
Sodium Channel
Parasite
COX
Antifungal
Potassium Channel
Glucocorticoid Receptor
DNA/RNA Synthesis
Estrogen/progestogen Receptor
Calcium Channel
Cytochromes P450
Ferroptosis
Topoisomerase
RAAS
SARS-CoV
VEGFR
Serotonin Transporter
Estrogen Receptor/ERR
Mitophagy
PDE
ribosome
c-Kit
Microtubule Associated
Dehydrogenase
Norepinephrine
HCV Protease
Reverse Transcriptase
GABA Receptor
Nucleoside Antimetabolite/Analog
EGFR
Progesterone Receptor
Antifection
PDGFR
PPAR
HSV
Proton pump
Reactive Oxygen Species
Androgen Receptor
Influenza Virus
ATPase
Carbonic Anhydrase
DNA Alkylator/Crosslinker
HBV
JAK
Prostaglandin Receptor
Cholinesterase (ChE)
FLT
HMG-CoA Reductase
Src
MAO
FGFR
Proteasome
Adenosine Receptor
Bcr-Abl
NF-κB
Thrombin
Thyroid hormone receptor(THR)
Phosphatase
MRP
Tyrosine Kinases
Raf
ROS
HDAC
c-RET
Transferase
DHFR
c-Met/HGFR
Virus Protease
PARP
Antifolate
ALK
Monoamine Oxidase
PI3K
TRP/TRPV Channel
iGluR
Drug Metabolite
Opioid Receptor
MMP
SGLT
HIF/HIF Prolyl-Hydroxylase
ABC Transporter
Endothelin Receptor
mTOR
P-gp
Retinoid Receptor
STAT
NO Synthase
P2Y Receptor
Factor Xa
PKC
CDK
DNA gyrase
DPP-4
DNA Alkylation
GluR
CaMK
MEK
DNA Methyltransferase
LPL Receptor
NMDAR
Guanylate cyclase
IL Receptor
Lipoxygenase
TLR
Trk receptor
AMPK
Phospholipase
HIF
TNF
HER
S1P Receptor
ADC Cytotoxin
Histone Methyltransferase
Integrin
NADPH
GNRH Receptor
ROCK
Monoamine Transporter
Hedgehog/Smoothened
Interleukin
Antiviral
HSP
Nrf2
Neurokinin receptor
TAM Receptor
ROS Kinase
CFTR
Cell wall
Glutathione Peroxidase
FXR
ERK
Annexin A
Molecular Glues
Isocitrate Dehydrogenase (IDH)
Vasopressin Receptor
DNA
Ligand for E3 Ligase
Aromatase
GPR
Hydroxylase
AhR
NOS
Reductase
Histone Demethylase
Cysteine Protease
Aryl Hydrocarbon Receptor
LDL
MT Receptor
Mitochondrial Metabolism
Smo
Fatty Acid Synthase
PAK
IGF-1R
Akt
GPCR19
Bcl-2 Family
Decarboxylase
Neprilysin
GST
c-Fms
CGRP Receptor
Complement System
Sigma receptor
Chloride channel
MicroRNA
CRM1
Amino Acids and Derivatives
Ligands for Target Protein for PROTAC
Arginase
Antioxidant
CETP
GSK-3
Melatonin Receptor
CaSR
Rho
Leukotriene Receptor
Caspase
CSF-1R
IRE1
UGT
Gamma-secretase
Na-K-Cl cotransporter
Integrase
CCR
CXCR
Xanthine Oxidase
Thrombopoietin Receptor
PGE Synthase
Beta-Secretase
Glutathione reductase
OAT
Free radical scavengers
Ephrin Receptor
GluCls
RSV
Beta Amyloid
Kras
Melanocortin Receptor
Oxytocin Receptor
Adenosine Deaminase
Gap Junction Protein
Syk
Ras
Protease-activated Receptor
BTK
NPC1L1
RAR/RXR
Hydrogenase
ROR
DNA-PK
p38 MAPK
YAP
IFNAR
JNK
gp120/CD4
TOPK
VDA
PKA
Cholecystokinin Receptor
Wnt/beta-catenin
Serine Protease
IAP
Myosin
Adiponectin Receptor
MTH1
GRK
Glucagon Receptor
P2X Receptor
GlyT
Glucosidase
PROTAC Linker
HCN Channel
FAAH
ACK1
Angiotensin-converting Enzyme (ACE)
Somatostatin
Chk
Epigenetic Reader Domain
DUB
Telomerase
TGF-beta/Smad
ATP Citrate Lyase
Lipid
MAPK
STING
CRFR
Pyroptosis
IκB/IKK
CRISPR/Cas9
PDK
Aquaporin
PLK
Platelet aggregation
Anti-infection
NADPH-oxidase
Tyrosinase
NOD-like Receptor (NLR)
PKM
Vitamin

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