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Taurodeoxycholic acid

Catalog No. T75319 CAS 516-50-7

Synonyms: Taurodeoxychloic acid

Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic acid inhibits apoptosis by blocking calcium-mediated apoptotic pathways and by activation of caspase-12. Taurodeoxycholic acid has neuroprotective activity and has been used to study 3-nitropropionic acid-induced or stabilized hereditary Huntington's chorea (HD).

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Taurodeoxycholic acid Chemical Structure

Taurodeoxycholic acid, CAS 516-50-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 56.00
5 mg	In stock	$ 118.00
10 mg	In stock	$ 171.00
25 mg	In stock	$ 287.00
50 mg	In stock	$ 465.00
100 mg	In stock	$ 682.00
500 mg	In stock	$ 1,430.00

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Purity: 99.09%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic acid inhibits apoptosis by blocking calcium-mediated apoptotic pathways and by activation of caspase-12. Taurodeoxycholic acid has neuroprotective activity and has been used to study 3-nitropropionic acid-induced or stabilized hereditary Huntington's chorea (HD).
In vitro	Taurodeoxycholic acid (50, 100 μM; 4 h) increases oligonuclear DNA cleavage and nuclear apoptosis in primary human hepatocytes.[1] Taurodeoxycholic acid (400 μM; 18-24 h) increases DNA fragmentation and PARP cleavage and induces apoptosis in human liver-derived Huh7 cells.[2]
In vivo	Taurodeoxycholic acid (50 mg/kg; i.p.; once daily for 34 days; Huntington's disease model in mice) prevents neuropathology and associated behavioral deficits in a rat model of Huntington's disease (HD).[3] Taurodeoxycholic acid (500 mg/kg; subcutaneous injection; every 3 days for 7 weeks; Huntington's disease model in mice) resulted in a significant reduction in striatal neuropathology in R6/2 transgenic HD mice.[4]

Synonyms	Taurodeoxychloic acid
Molecular Weight	499.7
Formula	C26H45NO6S
CAS No.	516-50-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL, (100 mM）, Sonication is recommended.

References and Literature

1. Benz C, et al. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Eur J Clin Invest. 2000;30(3):203-209. 2. Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002;36(3):592-601. 3. Keene CD, et al. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol. 2001;171(2):351-360. 4. Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A. 2002;99(16):10671-10676.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Bioactive Compounds Library Max Gut Microbial Metabolite Library Natural Product Library for HTS Human Metabolite Library Bioactive Compound Library

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Keywords

Taurodeoxycholic acid 516-50-7 Apoptosis Membrane transporter/Ion channel Metabolism Proteases/Proteasome Calcium Channel Caspase Taurodeoxychloic acid inhibitor inhibit

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