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ARRY-380 (analog )

Name: ARRY-380 (analog )
Brand: TargetMol
SKU: T2518
Price: 281 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2518Cas No. 937265-83-3

Alias HER2-Inhibitor-1, ARRY-380 analog, ARRY380

ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.

ARRY-380 (analog )

🥰Excellent

Purity: 99.82%

Catalog No. T2518Alias HER2-Inhibitor-1, ARRY-380 analog, ARRY380Cas No. 937265-83-3

ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.

Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$42	In Stock
5 mg	$68	In Stock
10 mg	$112	In Stock
25 mg	$189	In Stock
50 mg	$281	In Stock
100 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock

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Batch Information

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Purity:99.82%

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Bioactivity

Description	ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.
Targets&IC50	HER2:8 nM
Kinase Assay	The Millipore Kinase Profiler service is used to generate general selectivity data for SCH 900776 against a broad range of serine/threonine and tyrosine kinases. Assays are typically run at two concentrations of SCH 900776 (0.5 and 5 μM), at a fixed (10 μM) concentration of ATP. Data are provided as percent activity remaining, relative to uninhibited controls.
Synonyms	HER2-Inhibitor-1, ARRY-380 analog, ARRY380

Chemical Properties

Molecular Weight	569.63
Formula	C₂₉H₂₇N₇O₄S
Cas No.	937265-83-3
Smiles	Cc1cc(Nc2ncnc3ccc(cc23)-c2ccc(CNCCS(C)(=O)=O)o2)ccc1Oc1ccn2ncnc2c1
Relative Density.	1.43 g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91 mg/mL (159.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7555 mL	8.7776 mL	17.5553 mL	87.7763 mL
5 mM	0.3511 mL	1.7555 mL	3.5111 mL	17.5553 mL
10 mM	0.1756 mL	0.8778 mL	1.7555 mL	8.7776 mL
20 mM	0.0878 mL	0.4389 mL	0.8778 mL	4.3888 mL
50 mM	0.0351 mL	0.1756 mL	0.3511 mL	1.7555 mL
100 mM	0.0176 mL	0.0878 mL	0.1756 mL	0.8778 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc