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JC124

Name: JC124
Brand: TargetMol
SKU: T25548
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25548Cas No. 1638611-48-9

Alias JC-124, JC 124

JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.

JC124

😃Good

Purity: 99.64%

Catalog No. T25548Alias JC-124, JC 124Cas No. 1638611-48-9

JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	In Stock	In Stock
5 mg	$148	In Stock	In Stock
10 mg	$238	In Stock	In Stock
25 mg	$398	In Stock	In Stock
50 mg	$567	In Stock	In Stock
100 mg	$768	-	In Stock
200 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.64%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.
In vitro	JC124 selectively inhibits NLRP3 inflammasome formation and activates caspase-1, and reduces IL-1β[1].
In vivo	In adult male Sprague-Dawley rats bearing traumatic brain injury, intraperitoneal administration of JC124 (100 mg/kg) reduces the number of injury-induced degenerating neurons, inflammatory cell response, and cortical lesion volume. JC124 decreases the expression of NLRP3, IL-1 beta, TNFα, ASC, iNOS, and caspase-1[1].
Synonyms	JC-124, JC 124

Chemical Properties

Molecular Weight	382.86
Formula	C₁₇H₁₉ClN₂O₄S
Cas No.	1638611-48-9
Smiles	CNS(=O)(=O)c1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1
Relative Density.	1.304 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (587.68 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6119 mL	13.0596 mL	26.1192 mL	130.5960 mL
5 mM	0.5224 mL	2.6119 mL	5.2238 mL	26.1192 mL
10 mM	0.2612 mL	1.3060 mL	2.6119 mL	13.0596 mL
20 mM	0.1306 mL	0.6530 mL	1.3060 mL	6.5298 mL
50 mM	0.0522 mL	0.2612 mL	0.5224 mL	2.6119 mL
100 mM	0.0261 mL	0.1306 mL	0.2612 mL	1.3060 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc