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EG-011

Name: EG-011
Brand: TargetMol
SKU: T73498
Rating: 4.5 (1 reviews)

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Catalog No. T73498Cas No. 2377113-41-0

Alias EG011, EG 011

EG-011 is a first-in-class and potent activator of Wiskott-Aldrich syndrome protein (WASP) that relieves autoinhibition of WASP and robustly induces actin polymerization, EG-011 exhibits selective antitumor activity in lymphomas, supporting its use in cancer biology research to investigate cytoskeletal regulation, immune cell signaling, and WASP-driven tumor vulnerabilities.

EG-011

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Catalog No. T73498Alias EG011, EG 011Cas No. 2377113-41-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$764	8-10 weeks	8-10 weeks
100 mg	$1,190	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	EG-011 is a first-in-class and potent activator of Wiskott-Aldrich syndrome protein (WASP) that relieves autoinhibition of WASP and robustly induces actin polymerization, EG-011 exhibits selective antitumor activity in lymphomas, supporting its use in cancer biology research to investigate cytoskeletal regulation, immune cell signaling, and WASP-driven tumor vulnerabilities.
In vitro	In lymphoma cell lines (OCI-LY-19, REC1), EG-011 induced dose-dependent cell death (20-55%) at concentrations of 500 nM to 2 μM over 72 hours. Treatment (500 nM-5 μM) triggered actin polymerization in sensitive cells within 4-24 hours, while showing no cytotoxicity towards normal PBMCs even at high concentrations (1-10 mM) [1].
In vivo	In female NOD-SCID mice bearing Mantle Cell Lymphoma (MCL REC-1) xenografts, intraperitoneal (i.p.) administration of EG-011 (200 mg/kg, 5 days per week) delayed tumor progression. At the conclusion of the study, tumor volume in the treated group was 2.2-fold smaller than that of the control group (P < 0.001), without observations of systemic toxicity [1].
Synonyms	EG011, EG 011

Chemical Properties

Molecular Weight	482.53
Formula	C₂₈H₂₆N₄O₄
Cas No.	2377113-41-0
Smiles	O=C(C=C)N1CCCC(N2C(=O)C3=NC=CC=C3N(C2=O)CC4=CC=C(OC=5C=CC=CC5)C=C4)C1

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (207.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0724 mL	10.3621 mL	20.7241 mL	103.6205 mL
5 mM	0.4145 mL	2.0724 mL	4.1448 mL	20.7241 mL
10 mM	0.2072 mL	1.0362 mL	2.0724 mL	10.3621 mL
20 mM	0.1036 mL	0.5181 mL	1.0362 mL	5.1810 mL
50 mM	0.0414 mL	0.2072 mL	0.4145 mL	2.0724 mL
100 mM	0.0207 mL	0.1036 mL	0.2072 mL	1.0362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc