Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

EG-011

Name: EG-011
Brand: TargetMol
SKU: T73498
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T73498Cas No. 2377113-41-0

Alias EG011, EG 011

EG-011 is a first-in-class and potent activator of Wiskott-Aldrich syndrome protein (WASP) that relieves autoinhibition of WASP and robustly induces actin polymerization, EG-011 exhibits selective antitumor activity in lymphomas, supporting its use in cancer biology research to investigate cytoskeletal regulation, immune cell signaling, and WASP-driven tumor vulnerabilities.

EG-011

😃Good

Catalog No. T73498Alias EG011, EG 011Cas No. 2377113-41-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$764	8-10 weeks	8-10 weeks
100 mg	$1,190	8-10 weeks	8-10 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	EG-011 is a first-in-class and potent activator of Wiskott-Aldrich syndrome protein (WASP) that relieves autoinhibition of WASP and robustly induces actin polymerization, EG-011 exhibits selective antitumor activity in lymphomas, supporting its use in cancer biology research to investigate cytoskeletal regulation, immune cell signaling, and WASP-driven tumor vulnerabilities.
In vitro	In lymphoma cell lines (OCI-LY-19, REC1), EG-011 induced dose-dependent cell death (20-55%) at concentrations of 500 nM to 2 μM over 72 hours. Treatment (500 nM-5 μM) triggered actin polymerization in sensitive cells within 4-24 hours, while showing no cytotoxicity towards normal PBMCs even at high concentrations (1-10 mM) [1].
In vivo	In female NOD-SCID mice bearing Mantle Cell Lymphoma (MCL REC-1) xenografts, intraperitoneal (i.p.) administration of EG-011 (200 mg/kg, 5 days per week) delayed tumor progression. At the conclusion of the study, tumor volume in the treated group was 2.2-fold smaller than that of the control group (P < 0.001), without observations of systemic toxicity [1].
Synonyms	EG011, EG 011

Chemical Properties

Molecular Weight	482.53
Formula	C₂₈H₂₆N₄O₄
Cas No.	2377113-41-0
Smiles	O=C(C=C)N1CCCC(N2C(=O)C3=NC=CC=C3N(C2=O)CC4=CC=C(OC=5C=CC=CC5)C=C4)C1

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (207.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0724 mL	10.3621 mL	20.7241 mL	103.6205 mL
5 mM	0.4145 mL	2.0724 mL	4.1448 mL	20.7241 mL
10 mM	0.2072 mL	1.0362 mL	2.0724 mL	10.3621 mL
20 mM	0.1036 mL	0.5181 mL	1.0362 mL	5.1810 mL
50 mM	0.0414 mL	0.2072 mL	0.4145 mL	2.0724 mL
100 mM	0.0207 mL	0.1036 mL	0.2072 mL	1.0362 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc