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Parecoxib sodium

Name: Parecoxib sodium
Brand: TargetMol
SKU: T1780L
Rating: 4.5 (1 reviews)

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Catalog No. T1780LCas No. 198470-85-8

Alias SC-69124A, SC69124A, SC 69124A, Dynastat

Parecoxib sodium is a prodrug of Valdecoxib and a selective, orally active COX-2 inhibitor that suppresses prostaglandin (PG) synthesis and alleviates pain and inflammation. Parecoxib sodium also acts as a cannabinoid 1 (CB1) receptor agonist (EC50=2.4 µM).

Parecoxib sodium

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Catalog No. T1780LAlias SC-69124A, SC69124A, SC 69124A, DynastatCas No. 198470-85-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	7-10 days	7-10 days
25 mg	$48	7-10 days	7-10 days
50 mg	$73	7-10 days	7-10 days
100 mg	$123	7-10 days	7-10 days
500 mg	$297	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$53	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Parecoxib sodium is a prodrug of Valdecoxib and a selective, orally active COX-2 inhibitor that suppresses prostaglandin (PG) synthesis and alleviates pain and inflammation. Parecoxib sodium also acts as a cannabinoid 1 (CB1) receptor agonist (EC50=2.4 µM).
Targets&IC50	CB1:2.4 µM (EC50)
In vitro	Parecoxib sodium (0-200 μM; 24-48 h) dose-dependently inhibited GBM cell proliferation in GBM cells [4]. Parecoxib sodium (200 μM; 24-48 h) suppressed the migration capacity of U343 cells [4].
In vivo	Parecoxib sodium (2.5/5.0/10 mg/kg; intraperitoneal injection; once daily; 21 days) exhibited anxiolytic effects in the upright maze test and enhanced memory performance in the novel object recognition and Y-maze tests [3].
Synonyms	SC-69124A, SC69124A, SC 69124A, Dynastat

Chemical Properties

Molecular Weight	392.4
Formula	C₁₉H₁₇N₂NaO₄S
Cas No.	198470-85-8
Smiles	O=C(CC)N([Na])S(=O)(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (203.87 mM), Sonication is recommended.

H2O: 80.00 mg/mL (203.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5484 mL	12.7421 mL	25.4842 mL	127.4210 mL
5 mM	0.5097 mL	2.5484 mL	5.0968 mL	25.4842 mL
10 mM	0.2548 mL	1.2742 mL	2.5484 mL	12.7421 mL
20 mM	0.1274 mL	0.6371 mL	1.2742 mL	6.3710 mL
50 mM	0.0510 mL	0.2548 mL	0.5097 mL	2.5484 mL
100 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2742 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc