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BMT-124110

Name: BMT-124110
Brand: TargetMol
SKU: T10572
Price: 329 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10572Cas No. 1679371-59-5

BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM. BMT-090605 inhibits cyclin G-associated kinase GAK with an IC50 of 99 nM.

BMT-124110

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Purity: 98.07%

Catalog No. T10572Cas No. 1679371-59-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$329	-	In Stock
5 mg	$798	8-10weeks	8-10weeks
10 mg	$1,090	8-10weeks	8-10weeks
25 mg	$1,650	8-10weeks	8-10weeks
50 mg	$2,230	8-10weeks	8-10weeks
1 mL x 10 mM (in DMSO)	$953	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.07%

ee:98.44%

Appearance:Solid

Color:White

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COA HNMR ORP LCMS CSFC

Product Introduction

Bioactivity

Description	BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM. BMT-090605 inhibits cyclin G-associated kinase GAK with an IC50 of 99 nM.
Targets&IC50	GAK:99 nM, AAK1:0.9 nM
In vitro	BMT-124110 presents a cellular IC50 of 3.2 nM for AAK1[1].
In vivo	BMT-124110 is added directly to the spine by microion electrophoresis. Wind-induced activity decreased in 10 of the 14 animals.[1]

Chemical Properties

Molecular Weight	369.46
Formula	C₂₁H₂₇N₃O₃
Cas No.	1679371-59-5
Smiles	N(C(C)=O)C=1C=C2C=3C(=CC(OC[C@@](CC(C)C)(C)N)=CC3)OCC2=CN1
Relative Density.	1.189 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (74.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7067 mL	13.5333 mL	27.0665 mL	135.3326 mL
5 mM	0.5413 mL	2.7067 mL	5.4133 mL	27.0665 mL
10 mM	0.2707 mL	1.3533 mL	2.7067 mL	13.5333 mL
20 mM	0.1353 mL	0.6767 mL	1.3533 mL	6.7666 mL
50 mM	0.0541 mL	0.2707 mL	0.5413 mL	2.7067 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc