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Edasalonexent

Name: Edasalonexent
Brand: TargetMol
SKU: T15198
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15198Cas No. 1204317-86-1

Alias CAT-1004

Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor designed to improve Duchenne muscular dystrophy.

Edasalonexent

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Purity: 99.13%

Catalog No. T15198Alias CAT-1004Cas No. 1204317-86-1

Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor designed to improve Duchenne muscular dystrophy.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$60	-	In Stock
5 mg	$148	-	In Stock
10 mg	$238	-	In Stock
25 mg	$427	-	In Stock
50 mg	$672	-	In Stock
100 mg	$886	-	In Stock
1 mL x 10 mM (in DMSO)	$160	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.13%

Appearance:Oil

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor designed to improve Duchenne muscular dystrophy.
In vitro	Edasalonexent effectively inhibits the pathogenic NF-κB subunit p65/RelA in vitro[3].
In vivo	In vivo, Edasalonexent effectively improves the phenotype of mdx mice in terms of activity, muscle mass and function, injury, inflammation, fibrosis, and cardiac pathology associated with voluntary wheel running[3].
Synonyms	CAT-1004

Chemical Properties

Molecular Weight	490.68
Formula	C₃₁H₄₂N₂O₃
Cas No.	1204317-86-1
Smiles	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(=O)NCCNC(=O)c1ccccc1O
Relative Density.	1.031 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (163.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (5.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0380 mL	10.1899 mL	20.3799 mL	101.8994 mL
5 mM	0.4076 mL	2.0380 mL	4.0760 mL	20.3799 mL
10 mM	0.2038 mL	1.0190 mL	2.0380 mL	10.1899 mL
20 mM	0.1019 mL	0.5095 mL	1.0190 mL	5.0950 mL
50 mM	0.0408 mL	0.2038 mL	0.4076 mL	2.0380 mL
100 mM	0.0204 mL	0.1019 mL	0.2038 mL	1.0190 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc