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cis-Epoxysuccinic acid

Name: cis-Epoxysuccinic acid
Brand: TargetMol
SKU: T71921
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71921Cas No. 16533-72-5

Alias cis-2,3-Oxiranedicarboxylic Acid

cis-Epoxysuccinic acid is a potential agonist of Succinate receptor 1 and inhibitor of Isocitrate lyase 1 for use in biochemical experiments.

cis-Epoxysuccinic acid

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Purity: 99.81%

Catalog No. T71921Alias cis-2,3-Oxiranedicarboxylic AcidCas No. 16533-72-5

cis-Epoxysuccinic acid is a potential agonist of Succinate receptor 1 and inhibitor of Isocitrate lyase 1 for use in biochemical experiments.

Pack Size	Price	Availability
50 mg	$30	In Stock
100 mg	$42	In Stock
500 mg	$74	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Purity:99.81%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	cis-Epoxysuccinic acid is a potential agonist of Succinate receptor 1 and inhibitor of Isocitrate lyase 1 for use in biochemical experiments.
Targets&IC50	SUCNR1:2.7 μM (EC₅₀)
In vitro	In vitro, cis-Epoxysuccinic acid acts as a potent agonist of the succinate receptor (SUCNR1), with enhanced efficacy across several assays (e.g., cAMP inhibition, calcium mobilization, TGF-α shedding, and β-arrestin-3 recruitment). Cis-Epoxysuccinic acid suppresses cAMP levels with an EC₅₀ of 2.7 μM (pEC₅₀ = 5.57), making Cis-Epoxysuccinic acid approximately 10–20 times more potent than succinic acid[1].
In vivo	In vivo, cis-Epoxysuccinic acid significantly increases blood pressure in rats via SUCNR1 activation, demonstrating comparable potency to succinic acid[1].
Synonyms	cis-2,3-Oxiranedicarboxylic Acid

Chemical Properties

Molecular Weight	132.07
Formula	C₄H₄O₅
Cas No.	16533-72-5
Smiles	C(O)(=O)[C@H]1[C@@H](C(O)=O)O1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (1514.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.5717 mL	37.8587 mL	75.7174 mL	378.5871 mL
5 mM	1.5143 mL	7.5717 mL	15.1435 mL	75.7174 mL
10 mM	0.7572 mL	3.7859 mL	7.5717 mL	37.8587 mL
20 mM	0.3786 mL	1.8929 mL	3.7859 mL	18.9294 mL
50 mM	0.1514 mL	0.7572 mL	1.5143 mL	7.5717 mL
100 mM	0.0757 mL	0.3786 mL	0.7572 mL	3.7859 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc