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cis-Epoxysuccinic acid

Name: cis-Epoxysuccinic acid
Brand: TargetMol
SKU: T71921
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71921Cas No. 16533-72-5

Alias cis-2,3-Oxiranedicarboxylic Acid

cis-Epoxysuccinic acid is a potential agonist of Succinate receptor 1 and inhibitor of Isocitrate lyase 1 for use in biochemical experiments.

cis-Epoxysuccinic acid

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Purity: 99.81%

Catalog No. T71921Alias cis-2,3-Oxiranedicarboxylic AcidCas No. 16533-72-5

cis-Epoxysuccinic acid is a potential agonist of Succinate receptor 1 and inhibitor of Isocitrate lyase 1 for use in biochemical experiments.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$42	In Stock	In Stock
500 mg	$74	-	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.81%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	cis-Epoxysuccinic acid is a potential agonist of Succinate receptor 1 and inhibitor of Isocitrate lyase 1 for use in biochemical experiments.
Targets&IC50	SUCNR1:2.7 μM (EC₅₀)
In vitro	In vitro, cis-Epoxysuccinic acid acts as a potent agonist of the succinate receptor (SUCNR1), with enhanced efficacy across several assays (e.g., cAMP inhibition, calcium mobilization, TGF-α shedding, and β-arrestin-3 recruitment). Cis-Epoxysuccinic acid suppresses cAMP levels with an EC₅₀ of 2.7 μM (pEC₅₀ = 5.57), making Cis-Epoxysuccinic acid approximately 10–20 times more potent than succinic acid[1].
In vivo	In vivo, cis-Epoxysuccinic acid significantly increases blood pressure in rats via SUCNR1 activation, demonstrating comparable potency to succinic acid[1].
Synonyms	cis-2,3-Oxiranedicarboxylic Acid

Chemical Properties

Molecular Weight	132.07
Formula	C₄H₄O₅
Cas No.	16533-72-5
Smiles	C(O)(=O)[C@H]1[C@@H](C(O)=O)O1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (1514.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.5717 mL	37.8587 mL	75.7174 mL	378.5871 mL
5 mM	1.5143 mL	7.5717 mL	15.1435 mL	75.7174 mL
10 mM	0.7572 mL	3.7859 mL	7.5717 mL	37.8587 mL
20 mM	0.3786 mL	1.8929 mL	3.7859 mL	18.9294 mL
50 mM	0.1514 mL	0.7572 mL	1.5143 mL	7.5717 mL
100 mM	0.0757 mL	0.3786 mL	0.7572 mL	3.7859 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc