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(4E)-SUN9221
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Catalog No. T12596Cas No. 222318-55-0
(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist, exhibiting antihypertensive and antiplatelet aggregation activities in hypertensive rats.
(4E)-SUN9221
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Purity: 97.79%
Catalog No. T12596Cas No. 222318-55-0
(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist, exhibiting antihypertensive and antiplatelet aggregation activities in hypertensive rats.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $700 | - | In Stock | |
| 5 mg | $1,800 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.79%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist, exhibiting antihypertensive and antiplatelet aggregation activities in hypertensive rats. |
| Targets&IC50 | ADP:35 nM, Collagen:10 nM, Platelet aggregation:14 nM |
| In vitro | In human platelet-rich plasma (PRP), (4E)-SUN9221 potently inhibits collagen-, ADP-, and epinephrine-induced platelet aggregation, with IC50s of 10 nM, 35 nM, and 14 nM, respectively. Additionally, (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22)[1]. |
| In vivo | In conscious spontaneously hypertensive rats (SHR), (4E)-SUN9221 reduces blood pressure in a dose-dependent manner when administered orally at doses of 1, 3, and 10 mg/kg. Specifically, (4E)-SUN9221 at a dose of 3 mg/kg exhibits antihypertensive activity in SHR[1]. |
| Molecular Weight | 454.54 |
| Formula | C25H31FN4O3 |
| Cas No. | 222318-55-0 |
| Smiles | C(CCCN1CCC(C(=O)C2=CC=C(F)C=C2)CC1)N3C4=C(\C(=N\O)\CCN(C)C4=O)C=C3 |
| Relative Density. | 1.29 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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