Shopping Cart

Your shopping cart is currently empty

o-Phenanthroline

Name: o-Phenanthroline
Brand: TargetMol
SKU: T5983
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T5983Cas No. 66-71-7

Alias 1,10-Phenanthroline

o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation.

o-Phenanthroline

Copy Product Info

😃Good

Purity: 98.85%

Catalog No. T5983Alias 1,10-PhenanthrolineCas No. 66-71-7

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$44	In Stock	In Stock
500 mg	$66	-	In Stock
1 g	$86	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.85%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

o-Phenanthroline AI Summary

o-Phenanthroline exhibits a wide spectrum of bioactivities, including inhibitory effects on human farnesyltransferase with an IC50 of 4,000,000 nM, indicating its potential role in interfering with the farnesylation process. It demonstrates cytotoxic activity against both cisplatin-sensitive and -resistant A2780 ovarian cancer cell lines, with IC50 values of 3660.0 nM and 2730.0 nM, respectively. The compound inhibits N8-Acetylspermidine deacetylase from rat liver cytosol (Ki = 1,300,000 nM) and shows antibacterial activity against E. coli, P. aeruginosa, and S. aureus (MIC = 32.0 µg/mL). Additionally, o-Phenanthroline inhibits Chryseobacterium indologenes metallo-beta-lactamase (Ki = 7300.0 nM) and Pseudomonas aeruginosa VIM-1 and VIM-13 beta-lactamases with IC50 values of 73000.0 nM and 69300.0 nM, respectively. The compound demonstrates antimycobacterial activity against Mycobacterium smegmatis and varied inhibition of fungal, viral, and bacterial enzymes, including anthrax lethal factor and multiple matrix metalloproteinases. It inhibits acrAB AcrAB-TolC-mediated Nile Red efflux in E. coli and shows allosteric modulation at CCR8, CCR5, and CCR1 receptors. Moreover, o-Phenanthroline inhibits beta-lactamases in various bacterial strains, including NDM1, VIM2, and IMP1, and shows chelating activity that inhibits Clostridium botulinum enzyme activity (>95%). It also exhibits anti-tachyzoite activity against Toxoplasma gondii, with ED50 values of 2.01 µM and 2.28 µM after 72 and 96 hours, respectively, and a CC50 value of 70200.0 nM against NHDF cells, resulting in a selectivity index of 31.0. o-Phenanthroline possesses inhibitory potential against a variety of biological targets, making it a promising candidate for further pharmacological exploration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation.
Synonyms	1,10-Phenanthroline

Chemical Properties

Molecular Weight	180.21
Formula	C₁₂H₈N₂
Cas No.	66-71-7
Smiles	c1cnc2c(c1)ccc1cccnc21
Relative Density.	1.25 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (1387.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (11.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5491 mL	27.7454 mL	55.4908 mL	277.4541 mL
5 mM	1.1098 mL	5.5491 mL	11.0982 mL	55.4908 mL
10 mM	0.5549 mL	2.7745 mL	5.5491 mL	27.7454 mL
20 mM	0.2775 mL	1.3873 mL	2.7745 mL	13.8727 mL
50 mM	0.1110 mL	0.5549 mL	1.1098 mL	5.5491 mL
100 mM	0.0555 mL	0.2775 mL	0.5549 mL	2.7745 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc