Anti-CD50 Antibody (3C51) (Synonyms: intercellular adhesion molecule 3, ICAM-R, ICAM-3, CDW50, CD50)

Name: Anti-CD50 Antibody (3C51)
Brand: TargetMol
SKU: TMAY-00630
Rating: 4.5 (1 reviews)

Catalog No. TMAY-00630 Copy Product Info

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Anti-CD50 Antibody (3C51) is a Rabbit antibody targeting CD50. Anti-CD50 Antibody (3C51) can be used in IHC-P.

Anti-CD50 Antibody (3C51)

Copy Product Info

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Catalog No. TMAY-00630

Synonyms intercellular adhesion molecule 3, ICAM-R, ICAM-3, CDW50, CD50

Anti-CD50 Antibody (3C51) is a Rabbit antibody targeting CD50. Anti-CD50 Antibody (3C51) can be used in IHC-P.

Anti-CD50 Antibody
(3C51)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$270	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-CD50 Antibody (3C51) is a Rabbit antibody targeting CD50. Anti-CD50 Antibody (3C51) can be used in IHC-P.
Synonyms	intercellular adhesion molecule 3, ICAM-R, ICAM-3, CDW50, CD50
Ig Type	Rabbit IgG
Clone	3C51
Reactivity	Human
Specificity	Human ICAM-3/CD50 No cross-reactivity in ELISA with Mouse ICAM1 Human ICAM Human VCAM1 Mouse VCAM1
Verified Activity	1. Immunochemical staining of human ICAM3 in human tonsil with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human ICAM3 in human spleen with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Application	IHC-P
Recommended Dose	IHC-P: 1:100-1:500
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Human CD50 / ICAM-3 (rh CD50 / ICAM-3; TMPY-01430; CAA49369.1; Met1-His485).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	The protein ICAM-3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting of three members. It is a DC-SIGN ligand that is constitutively expressed on resting leukocytes and is thus an important molecule for the first immune response. ICAM-3 comprises five immunoglobulin-like domains and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule but also as a potent signaling molecule. ICAM-3 binds to LFA-1 on antigen-presenting cells (APC) stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex. However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling. It has been reported that the CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. Also, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells. ICAM-3 is associated with an increase in cellular radio-resistance and cancer cell proliferation. It could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human CD50 / ICAM-3 protein (TMPY-01430)
Antigen Species	Human

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.