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BIRM 271

Name: BIRM 271
Brand: TargetMol
SKU: T77638
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77638Cas No. 149106-77-4

BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leukotriene B4 with IC50 of 40 nM.

BIRM 271

🥰Excellent

Purity: 99.64%

Catalog No. T77638Cas No. 149106-77-4

Pack Size	Price	Availability
1 mg	$82	In Stock
5 mg	$181	In Stock
10 mg	$267	In Stock
25 mg	$413	In Stock
50 mg	$592	In Stock
100 mg	$819	In Stock
200 mg	$1,090	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.64%

ee:100%

Resource Download

COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	335.44
Formula	C₂₁H₂₅N₃O
Cas No.	149106-77-4
Smiles	N([C@H](CC1CCCCC1)C2=CC=CC=N2)C=3OC=4C(N3)=CC(C)=CC4
Relative Density.	1.160 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (149.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9812 mL	14.9058 mL	29.8116 mL	149.0580 mL
5 mM	0.5962 mL	2.9812 mL	5.9623 mL	29.8116 mL
10 mM	0.2981 mL	1.4906 mL	2.9812 mL	14.9058 mL
20 mM	0.1491 mL	0.7453 mL	1.4906 mL	7.4529 mL
50 mM	0.0596 mL	0.2981 mL	0.5962 mL	2.9812 mL
100 mM	0.0298 mL	0.1491 mL	0.2981 mL	1.4906 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc