Renin Protein, Human, Recombinant (R66K, His)

Name: Renin Protein, Human, Recombinant (R66K, His)
Brand: TargetMol
SKU: TMPY-05808
Rating: 4.5 (1 reviews)

(Synonyms: renin, REN, HNFJ2, FLJ10761) Copy Product Info

Synonyms: renin, REN, HNFJ2, FLJ10761

Catalog No. TMPY-05808 Copy Product Info

Renin Protein, Human, Recombinant (R66K, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.74 kDa and the accession number is P00797-1.

Pack Size	Price	EUR Stock	Global Stock
5 µg	76 €	7-10 days	7-10 days
10 µg	131 €	7-10 days	7-10 days
20 µg	217 €	7-10 days	7-10 days
50 µg	429 €	7-10 days	7-10 days
100 µg	836 €	7-10 days	7-10 days

For In stock only · Estimated delivery: EUR Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Renin Protein, Human, Recombinant (R66K, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.74 kDa and the accession number is P00797-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P00797-1
Construction	A DNA sequence encoding the human REN (NP_000528.1, with mutation Arg 66 Lys) (Met1-Arg406) was expressed with a polyhistide tag at the C-terminus. Predicted N terminal: Leu 24
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 150 mM NaCl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	renin, REN, HNFJ2, FLJ10761
Research Background	Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.

Chemical Properties

Molecular Weight

43.74 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.