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LY3295668

Name: LY3295668
Brand: TargetMol
SKU: T15815
Price: 87 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15815Cas No. 1919888-06-4

Alias AK-01

LY3295668 (AK-01) is a selective inhibitor of Aurora A, with Ki values of 0.8 nM for Aurora A and 1038 nM for Aurora B.

LY3295668

🥰Excellent

Purity: 99.68%

Catalog No. T15815Alias AK-01Cas No. 1919888-06-4

LY3295668 (AK-01) is a selective inhibitor of Aurora A, with Ki values of 0.8 nM for Aurora A and 1038 nM for Aurora B.

Pack Size	Price	Availability
1 mg	$87	In Stock
5 mg	$213	In Stock
10 mg	$317	In Stock
25 mg	$513	In Stock
50 mg	$708	In Stock
100 mg	$953	In Stock
200 mg	$1,280	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.68%

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	LY3295668 (AK-01) is a selective inhibitor of Aurora A, with Ki values of 0.8 nM for Aurora A and 1038 nM for Aurora B.
Targets&IC50	Aurora A:0.8 nM
In vitro	LY3295668 kills Rb-deficient cancer cells with minimal effects on normal cells[1].
Synonyms	AK-01

Chemical Properties

Molecular Weight	489.95
Formula	C₂₄H₂₆ClF₂N₅O₂
Cas No.	1919888-06-4
Smiles	C[C@@H]1C[C@@](Cc2nc(Nc3cc(C)[nH]n3)ccc2F)(CCN1Cc1cccc(Cl)c1F)C(O)=O
Relative Density.	1.390 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (183.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0410 mL	10.2051 mL	20.4102 mL	102.0512 mL
5 mM	0.4082 mL	2.0410 mL	4.0820 mL	20.4102 mL
10 mM	0.2041 mL	1.0205 mL	2.0410 mL	10.2051 mL
20 mM	0.1021 mL	0.5103 mL	1.0205 mL	5.1026 mL
50 mM	0.0408 mL	0.2041 mL	0.4082 mL	2.0410 mL
100 mM	0.0204 mL	0.1021 mL	0.2041 mL	1.0205 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc