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Leptomycin B

Name: Leptomycin B
Brand: TargetMol
SKU: T15735
Price: 213 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15735Cas No. 87081-35-4

Alias LMB, CI 940

Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue.

Leptomycin B

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Purity: 99.04%

Catalog No. T15735Alias LMB, CI 940Cas No. 87081-35-4

Pack Size	Price	Availability
1 mg	$213	In Stock
2 mg	$359	In Stock
5 mg	$652	In Stock
10 mg	$928	In Stock
25 mg	$1,390	In Stock
50 mg	$1,870	In Stock
100 mg	$2,530	In Stock
1 mL x 10 mM (in DMSO)	$297	In Stock

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Purity:99.04%

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Product Introduction

Bioactivity

Description	Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue.
Synonyms	LMB, CI 940

Chemical Properties

Molecular Weight	540.73
Formula	C₃₃H₄₈O₆
Cas No.	87081-35-4
Smiles	CC\C(\C=C\[C@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O
Relative Density.	1.072 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 101 mg/mL (186.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8494 mL	9.2468 mL	18.4935 mL	92.4676 mL
5 mM	0.3699 mL	1.8494 mL	3.6987 mL	18.4935 mL
10 mM	0.1849 mL	0.9247 mL	1.8494 mL	9.2468 mL
20 mM	0.0925 mL	0.4623 mL	0.9247 mL	4.6234 mL
50 mM	0.0370 mL	0.1849 mL	0.3699 mL	1.8494 mL
100 mM	0.0185 mL	0.0925 mL	0.1849 mL	0.9247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc