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Methionine

Name: Methionine
Brand: TargetMol
SKU: T19418L
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19418LCas No. 348-67-4

Alias MRX-1024, D-Methionine

Methionine (D-Methionine) (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

Methionine

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Purity: 99.62%

Catalog No. T19418LAlias MRX-1024, D-MethionineCas No. 348-67-4

Methionine (D-Methionine) (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$29	In Stock	In Stock
5 g	$42	7-10 days	7-10 days
10 g	$59	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.62%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Methionine (D-Methionine) (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
In vitro	When human plasma is incubated with Methionine (D-methionine) and CP, a Pt-D-methionine complex forms, regardless of the sequence in which they are added. Initially, an early CP hydrolysis product combines with Methionine to create a 1:1 complex, which subsequently leads to a 2:1 compound over time. These Pt-D-methionine compounds are crucial in how Methionine shields mammalian organisms from CP-induced toxicities[2].
In vivo	Administration of Methionine (D-methionine) concurrently with cisplatin results in a cell density of 0.8±0.070 (SEM), which is significantly higher than that observed in rats receiving cisplatin alone (P<0.01), yet comparable to control groups and those treated with D-methionine only (P>0.05). Solo administration of Methionine yields an average cell density of 0.95±0.099 (SEM), also showing no significant difference from controls (P>0.05)[3].
Synonyms	MRX-1024, D-Methionine

Chemical Properties

Molecular Weight	149.21
Formula	C₅H₁₁NO₂S
Cas No.	348-67-4
Smiles	[C@H](C(O)=O)(CCSC)N

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 15.7 mg/mL (105.22 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.7020 mL	33.5098 mL	67.0196 mL	335.0982 mL
5 mM	1.3404 mL	6.7020 mL	13.4039 mL	67.0196 mL
10 mM	0.6702 mL	3.3510 mL	6.7020 mL	33.5098 mL
20 mM	0.3351 mL	1.6755 mL	3.3510 mL	16.7549 mL
50 mM	0.1340 mL	0.6702 mL	1.3404 mL	6.7020 mL
100 mM	0.0670 mL	0.3351 mL	0.6702 mL	3.3510 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc