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Methionine

Catalog No. T19418L CAS 348-67-4

Synonyms: D-Methionine, MRX-1024

Methionine (D-Methionine) (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

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Methionine, CAS 348-67-4

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Purity: 99.52%

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Description	Methionine (D-Methionine) (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
In vitro	When human plasma is incubated with Methionine (D-methionine) and CP, a Pt-D-methionine complex forms, regardless of the sequence in which they are added. Initially, an early CP hydrolysis product combines with Methionine to create a 1:1 complex, which subsequently leads to a 2:1 compound over time. These Pt-D-methionine compounds are crucial in how Methionine shields mammalian organisms from CP-induced toxicities[2].
In vivo	Administration of Methionine (D-methionine) concurrently with cisplatin results in a cell density of 0.8±0.070 (SEM), which is significantly higher than that observed in rats receiving cisplatin alone (P<0.01), yet comparable to control groups and those treated with D-methionine only (P>0.05). Solo administration of Methionine yields an average cell density of 0.95±0.099 (SEM), also showing no significant difference from controls (P>0.05)[3].

Synonyms	D-Methionine, MRX-1024
Molecular Weight	149.21
Formula	C5H11NO2S
CAS No.	348-67-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 22.5 mg/mL (150.8 mM), Sonication is recommended.

References and Literature

1. Wu C, et al. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. J Neural Transm (Vienna). 2014 Jul;121(7):683-93. 2. Sooriyaarachchi M, et al. Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitrostudies using human plasma. Metallomics. 2014 Mar;6(3):532-41. 3. Hinduja S, et al. D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotox Res. 2015 Apr;27(3):199-204.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max Antidepressant Compound Library Approved Drug Library Gut Microbial Metabolite Library Human Metabolite Library Clinical Compound Library

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Keywords

Methionine 348-67-4 Metabolism Endogenous Metabolite MRX1024 MRX 1024 D-Methionine MRX-1024 inhibitor inhibit

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