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YAP/TAZ inhibitor-1

Name: YAP/TAZ inhibitor-1
Brand: TargetMol
SKU: T13364
Rating: 4.5 (1 reviews)

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Catalog No. T13364Cas No. 2093565-23-0

YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.

YAP/TAZ inhibitor-1

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Purity: 99.72%

Catalog No. T13364Cas No. 2093565-23-0

YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.

Pack Size	Price	Availability
2 mg	$487	5 days
5 mg	$826	5 days
1 mL x 10 mM (in DMSO)	$1,150	5 days

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Purity:99.72%

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COA LCMS

Product Introduction

Bioactivity

Description	YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.
In vitro	YAP/TAZ inhibitor-1 is an inhibitor of the transcriptional coactivator with PDZ-binding motif/Yes-associated protein transcriptional coactivator (TAZ/YAP), exerting significant anti-proliferative effects in cells[1].

Chemical Properties

Molecular Weight	621.81
Formula	C₃₃H₃₉N₃O₅S₂
Cas No.	2093565-23-0
Smiles	CC(N1CCN(CC1)S(=O)(=O)c1ccc2-c3ccc(cc3\C(=N/O)c2c1)S(=O)(=O)C1CCC(C)(C)CC1)c1ccccc1
Relative Density.	1.35 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (128.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6082 mL	8.0410 mL	16.0821 mL	80.4104 mL
5 mM	0.3216 mL	1.6082 mL	3.2164 mL	16.0821 mL
10 mM	0.1608 mL	0.8041 mL	1.6082 mL	8.0410 mL
20 mM	0.0804 mL	0.4021 mL	0.8041 mL	4.0205 mL
50 mM	0.0322 mL	0.1608 mL	0.3216 mL	1.6082 mL
100 mM	0.0161 mL	0.0804 mL	0.1608 mL	0.8041 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc