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ES 936

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Catalog No. T22769Cas No. 192820-78-3
Alias ES936

ES 936 is a potent and selective NQO1 inhibitor, inhibiting more than 95% of NQO1 activity within 30 minutes at a concentration of 100 nM, with a cell line-dependent inhibition duration resulting in a small number of DNA strand breaks.

ES 936

ES 936

🥰Excellent
Catalog No. T22769Alias ES936Cas No. 192820-78-3
ES 936 is a potent and selective NQO1 inhibitor, inhibiting more than 95% of NQO1 activity within 30 minutes at a concentration of 100 nM, with a cell line-dependent inhibition duration resulting in a small number of DNA strand breaks.
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1 mg$70 In Stock
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Product Introduction

Bioactivity
Description
ES 936 is a potent and selective NQO1 inhibitor, inhibiting more than 95% of NQO1 activity within 30 minutes at a concentration of 100 nM, with a cell line-dependent inhibition duration resulting in a small number of DNA strand breaks.
Targets&IC50
Streptonigrin cytotoxicity in HCT116 cells (with ES936 pretreatment):11 ± 0.6 nM, Streptonigrin cytotoxicity in HCT116 cells (without ES936 pretreatment):6.7 ± 1 nM, Cell proliferation (reflecting cytotoxicity) in MDA468 NQ-16 cells:732 ± 49 nM, Streptonigrin cytotoxicity in MDA468 NQ-16 cells (without ES936 pretreatment):2.2 ± 0.06 nM, Cell proliferation in HCT116 cells:569 ± 48 nM, Streptonigrin cytotoxicity in MDA468 NQ-16 cells (with ES936 pretreatment):13 ± 0.4 nM 
In vitro
ES 936 exhibited relatively low cytotoxicity toward MDA468 NQ-16 (high NQO1 activity) and HCT116 (low NQO1 activity) cells, with IC₅₀ values of 732 ± 49 nM and 569 ± 48 nM, respectively. These concentrations are approximately 8–20 times higher than those required for effective NQO1 inhibition, indicating weak intrinsic growth-inhibitory activity.[1] In co-treatment experiments, ES 936 pretreatment significantly increased the IC₅₀ of streptonigrin, from 2.2 ± 0.06 nM to 13 ± 0.4 nM in MDA468 NQ-16 cells (approximately 6-fold), and from 6.7 ± 1 nM to 11 ± 0.6 nM in HCT116 cells (approximately 2-fold). These results indicate that ES 936 reduces the bioactivation and cytotoxicity of streptonigrin by inhibiting NQO1 activity.[1]
AliasES936
Chemical Properties
Molecular Weight356.33
FormulaC18H16N2O6
Cas No.192820-78-3
SmilesO=C1C=C(OC)C(=O)C2=C1N(C(=C2COC3=CC=C(C=C3)N(=O)=O)C)C
Relative Density.1.38 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 1 mg/mL (2.81 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8064 mL14.0319 mL28.0639 mL140.3194 mL

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