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Thalidomide-NH-C4-NH-Boc

Name: Thalidomide-NH-C4-NH-Boc
Brand: TargetMol
SKU: T18807
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18807Cas No. 2093388-52-2

Thalidomide-NH-C4-NH-Boc is a synthesized conjugate used in PROTAC technology, combining a Thalidomide-based cereblon ligand with a linker.

Thalidomide-NH-C4-NH-Boc

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Purity: 98.87%

Catalog No. T18807Cas No. 2093388-52-2

Thalidomide-NH-C4-NH-Boc is a synthesized conjugate used in PROTAC technology, combining a Thalidomide-based cereblon ligand with a linker.

Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$48	In Stock
25 mg	$96	In Stock
50 mg	$159	In Stock
100 mg	$257	In Stock
200 mg	$359	In Stock

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Batch Information

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Purity:98.87%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Thalidomide-NH-C4-NH-Boc is a synthesized conjugate used in PROTAC technology, combining a Thalidomide-based cereblon ligand with a linker.

Chemical Properties

Molecular Weight	444.48
Formula	C₂₂H₂₈N₄O₆
Cas No.	2093388-52-2
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCNC(OC(C)(C)C)=O
Relative Density.	1.324 g/cm3 (Predicted)
Color	Green
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (112.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2498 mL	11.2491 mL	22.4982 mL	112.4910 mL
5 mM	0.4500 mL	2.2498 mL	4.4996 mL	22.4982 mL
10 mM	0.2250 mL	1.1249 mL	2.2498 mL	11.2491 mL
20 mM	0.1125 mL	0.5625 mL	1.1249 mL	5.6246 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2498 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1249 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc