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GNE-8324

Name: GNE-8324
Brand: TargetMol
SKU: T31981
Price: 153 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31981Cas No. 1698901-76-6

Alias GNE8324, GNE 8324

GNE-8324 is a GluN2A selective positive allosteric modulator that selectively enhances NMDAR-mediated synaptic responses in inhibitory, but not excitatory, neurons.GNE-8324 is used in the study of neurological disorders.

GNE-8324

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Purity: 99.34%

Catalog No. T31981Alias GNE8324, GNE 8324Cas No. 1698901-76-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$153	In Stock	In Stock
5 mg	$378	In Stock	In Stock
10 mg	$559	In Stock	In Stock
25 mg	$893	In Stock	In Stock
50 mg	$1,180	In Stock	In Stock
100 mg	$1,620	In Stock	In Stock
200 mg	$2,180	-	In Stock
1 mL x 10 mM (in DMSO)	$387	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.34%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	GNE-8324 is a GluN2A selective positive allosteric modulator that selectively enhances NMDAR-mediated synaptic responses in inhibitory, but not excitatory, neurons.GNE-8324 is used in the study of neurological disorders.
In vitro	At GluN2A-type NMDARs, there is a reciprocal allosteric interaction between the binding sites for GNE-8324 and glutamate, meaning that glutamate binding promotes the binding of GNE-8324, and vice versa. GNE-8324 selectively enhances NMDARs containing the GluN2A subunit, with its potentiating effect significantly dependent on the occupancy of the glutamate site. The binding affinity of GNE-8324 is markedly higher in glutamate-bound NMDARs compared to those without bound glutamate. [1]
Synonyms	GNE8324, GNE 8324

Chemical Properties

Molecular Weight	343.42
Formula	C₁₈H₁₈FN₃OS
Cas No.	1698901-76-6
Smiles	O=C1C=C(N=C2SC3=C(N12)CCC3)CN(C4=CC=C(F)C=C4)CC
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (232.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9119 mL	14.5594 mL	29.1189 mL	145.5943 mL
5 mM	0.5824 mL	2.9119 mL	5.8238 mL	29.1189 mL
10 mM	0.2912 mL	1.4559 mL	2.9119 mL	14.5594 mL
20 mM	0.1456 mL	0.7280 mL	1.4559 mL	7.2797 mL
50 mM	0.0582 mL	0.2912 mL	0.5824 mL	2.9119 mL
100 mM	0.0291 mL	0.1456 mL	0.2912 mL	1.4559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc