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Epsilon-V1-2

Name: Epsilon-V1-2
Brand: TargetMol
SKU: T35827
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35827Cas No. 182683-50-7

Alias ε-V1-2, Protein Kinase Cɛ Inhibitor Peptide, PKCε Inhibitor Peptide, ɛV1-2, EAVSLKPT

Epsilon-V1-2 has been extensively investigated for its function as a PKC epsilon (PKCε) inhibitor. Epsilon-V1-2 has been widely applied in studies addressing ovarian aging, apoptosis in human granulosa cells, cerebral ischemia-reperfusion injury, brain development, hepatocyte insulin signaling, and neuronal cell death under ischemic conditions. Epsilon-V1-2 has been shown to effectively reduce PKCε activity, thereby enabling detailed exploration of regulatory pathways involving mitochondrial dynamics, calcium overload, AKT activation, brain atrophy, insulin resistance, and ferroptosis. Epsilon-V1-2 demonstrates notable therapeutic relevance in models of stroke, SHORT syndrome, hepatic steatosis, and brain injury, supporting its continued evaluation as a potential pharmacological agent across multiple disease contexts.

Epsilon-V1-2

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Purity: 97.09%

Catalog No. T35827Alias ε-V1-2, Protein Kinase Cɛ Inhibitor Peptide, PKCε Inhibitor Peptide, ɛV1-2, EAVSLKPTCas No. 182683-50-7

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$113	-	In Stock
1 mg	$178	-	In Stock
5 mg	$833	-	In Stock
10 mg	$1,530	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.09%

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COA MS HPLC

Product Introduction

Bioactivity

Description	Epsilon-V1-2 has been extensively investigated for its function as a PKC epsilon (PKCε) inhibitor. Epsilon-V1-2 has been widely applied in studies addressing ovarian aging, apoptosis in human granulosa cells, cerebral ischemia-reperfusion injury, brain development, hepatocyte insulin signaling, and neuronal cell death under ischemic conditions. Epsilon-V1-2 has been shown to effectively reduce PKCε activity, thereby enabling detailed exploration of regulatory pathways involving mitochondrial dynamics, calcium overload, AKT activation, brain atrophy, insulin resistance, and ferroptosis. Epsilon-V1-2 demonstrates notable therapeutic relevance in models of stroke, SHORT syndrome, hepatic steatosis, and brain injury, supporting its continued evaluation as a potential pharmacological agent across multiple disease contexts.
In vitro	Epsilon-V1-2 (1 μM, 24 hours) significantly inhibits OA-induced Cx43 Ser368 phosphorylation and protects myocardial gap junctions from OA-induced disruption [2].
In vivo	Epsilon-V1-2 (20 mg/kg/day, subcutaneously implanted with 0.1 mL osmotic pump, administered daily for 4 weeks) significantly improved the beating score of transplanted FVB mouse hearts in C57BL/6J mice [3].
Synonyms	ε-V1-2, Protein Kinase Cɛ Inhibitor Peptide, PKCε Inhibitor Peptide, ɛV1-2, EAVSLKPT

Chemical Properties

Molecular Weight	843.98
Formula	C₃₇H₆₅N₉O₁₃
Cas No.	182683-50-7
Smiles	C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)C)=O)[C@H](C)C)=O)CO)=O)CC(C)C)=O)CCCCN)(=O)N1[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CCC1
Color	White
Appearance	Solid
Sequence	H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH
Sequence Short	EAVSLKPT

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100.00 mg/mL (118.49 mM), Sonication is recommended.

H2O: ≥ 80 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1849 mL	5.9243 mL	11.8486 mL	59.2431 mL
5 mM	0.2370 mL	1.1849 mL	2.3697 mL	11.8486 mL
10 mM	0.1185 mL	0.5924 mL	1.1849 mL	5.9243 mL
20 mM	0.0592 mL	0.2962 mL	0.5924 mL	2.9622 mL
50 mM	0.0237 mL	0.1185 mL	0.2370 mL	1.1849 mL
100 mM	0.0118 mL	0.0592 mL	0.1185 mL	0.5924 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc