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Omidenepag isopropyl

Name: Omidenepag isopropyl
Brand: TargetMol
SKU: T16388
Price: 780 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16388Cas No. 1187451-19-9

Alias DE-117, DE117, DE 117

Omidenepag isopropyl (DE-117) is a selective prostaglandin EP2 receptor agonist and a novel topical ocular blood pressure lowering compound.Omidenepag isopropyl has a weak affinity for EP1, EP2, and FP receptors.Omidenepag isopropyl is used in studies of glaucoma and hypertension. Omidenepag isopropyl can be used to study glaucoma and hypertension.

Omidenepag isopropyl

🥰Excellent

Purity: 99.86%

Catalog No. T16388Alias DE-117, DE117, DE 117Cas No. 1187451-19-9

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$780	In Stock	In Stock
50 mg	$980	In Stock	In Stock
100 mg	$1,770	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.86%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Omidenepag isopropyl (DE-117) is a selective prostaglandin EP2 receptor agonist and a novel topical ocular blood pressure lowering compound.Omidenepag isopropyl has a weak affinity for EP1, EP2, and FP receptors.Omidenepag isopropyl is used in studies of glaucoma and hypertension. Omidenepag isopropyl can be used to study glaucoma and hypertension.
In vitro	METHODS: All binding studies were performed on prostaglandin receptors DP1, EP1-4, FP, and IP at OMDI (0.1, 0.3, 1, 3, and 10 μM) in all assays, calculated using the Cheng-Prusoff equation. RESULTS: OMDI binds weakly to the EP1 receptor with Ki = 1700 nM, to the EP2 receptor with Ki > 4600 nM, and to the FP receptor with Ki > 4500 nM. [2]
In vivo	METHODS: The effects of Omidenepag isopropyl on intraocular pressure and aqueous humor dynamics were evaluated in cynomolgus monkeys with unilateral laser-induced intraocular hypertension. In a crossover fashion, the hypertensive eye of each monkey was dosed once daily with 20 μL of 0.002% Omidenepag isopropyl or vehicle. On day 7 of dosing, IOP was measured by pneumometry, aqueous humor flow and outflow facilities were assessed by fluorophotometry, and uveoscleral outflow was calculated mathematically. Treatments were compared by paired t test. RESULTS: Omidenepag isopropyl significantly reduced intraocular pressure by 27%, 35% and 44% at 0.5, 1.5 and 4 hours after the last administration; Omidenepag isopropyl treatment group and uveoscleral outflow significantly increased by 71% and 176% respectively. (P<0.05). [1]
Synonyms	DE-117, DE117, DE 117

Chemical Properties

Molecular Weight	520.6
Formula	C₂₆H₂₈N₆O₄S
Cas No.	1187451-19-9
Smiles	O=C(OC(C)C)CNC=1N=C(C=CC1)CN(CC2=CC=C(C=C2)N3N=CC=C3)S(=O)(=O)C=4C=NC=CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (76.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9209 mL	9.6043 mL	19.2086 mL	96.0430 mL
5 mM	0.3842 mL	1.9209 mL	3.8417 mL	19.2086 mL
10 mM	0.1921 mL	0.9604 mL	1.9209 mL	9.6043 mL
20 mM	0.0960 mL	0.4802 mL	0.9604 mL	4.8022 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc